Head of Mammalian Reproduction research group at the Central European Institute of Technology (CEITEC) & Head of Cell Division Control laboratory, Institute of Animal Physiology and Genetics AS CR.
Training: Dental Research, Bioengineering.
Postdoctoral: TGF-beta, wound healing, regeneration, radiation biology, light biology, stem cells, biomaterial, Lasers.
Current: Clinical translational research and Molecular mechanisms.
Positions: Past-President, NAALT; President-Elect WALT, Co-Chair SPIE, Chair, ASLMS
Interests: Signal Transduction, Lasers, Biological regulation.
Research Group Leader, Max Planck Institute for Molecular Biomedicine. Research topics: cell-to-cell communication in development and regeneration of tissues, stem cell regulation, invertebrate model organisms.
Professor of Biology at the University of Antwerp. Member of the Flemish Science Foundation review board. Editor of the journals Journal of Plant Research, Frontiers in Plant Science and PLOS ONE
--- CURRENT POSITION ---
° Founder and Honorary Director of INMED (Institut de Neurobiologie de la Méditerranée), INSERM U901, Marseille, France
° Professor of Neurobiology, Université René Descartes Paris V, France and Liège (honoris causae)
--- EDUCATION ---
° 1973-1979 - Post-doctoral & sabbatical studies: University of Cambridge (UK), University of Oslo (Norway) and McGill University (Canada)
° 1971 - Doctorat ès-sciences, Université de Paris VI (France)
° 1966 - B Sc. Biochemistry-Physiology, Hebrew University of Jerusalem (Israel)
--- AWARDS ---
° 2014 - Finalist Créa13 -Neurochlore
° 2013 - Award « Tremplins de La Provence » - Neurochlore
° 2012 - Award of the of the FNRS ( Fonds de la Recherche Scientifique de Belgique) of Belgium
° 2010 - Award of the European Society of Epilepsy
° 2009 - Award of the Grand Prix de la Recherche médicale de l'INSERM
° 2009 - Docteur Honoris causae, Liège University (Belgium)
° 2006 - Rotary Brain Research Award
° 2002 - The Health Price (Grand Prix de la Santé) of the Foundation of French Electricity ° 2000 - The American Epilepsy Society Research Award for outstanding research in epilepsies
Assistant Professor of Integrative Biology and Pharmacology at University of Texas Medical School at Houston. Member of the Graduate School of Biomedical Sciences program (UT Houston). Expertise in kinase-mediated cell signaling, transcriptional regulation, skeletal muscle and hepatic metabolism and muscle regeneration.
1981-1985. Graduate Student, MRC Laboratory of Molecular Biology, Cambridge, U.K.
1985-1989. Postdoctoral Fellow Department of Biochemistry, University of California, Berkeley, CA.
1989-2000. Assistant and Associate Professor, Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT.
2000- Staff Scientist, Genomics Division, Lawrence Berkeley National Laboratory, Berkeley CA.
Professor of Developmental Biology in the Laboratory of Molecular Biology, Department of Plant Sciences, Wageningen University, The Netherlands.
Distinguished Scientist at Lawrence Berkeley National Laboratory, University Calif. Awards include ACS Medal of Honor, Lawrence Prize and Medal, Pezcollar-AACR Prize, Komen Foundation Brinker Award and Mina J. Bissell Award. More than 120 named and distinguished lectures. Past-President: American Soc. Cell Biology and Int. Society of Differentiation. Elected to the US National Academy, the IOM, American Philosophical Society, AAAS and the American Academy of Arts and Sciences
My primary research field is mammalian epigenetic control. My interests lie in using screens to identify novel epigenetic modifiers or new roles for known epigenetic modifiers, in order that we can expand our understanding of the molecular basis of epigenetic control. We study X chromosome inactivation in differentiating ES cells and early embryos, haematopoietic stem cells, neural stem cells and additionally study the role of the epigenetic modifier Smchd1 in the muscular dystrophy FSHD.
2013- Senior Lecturer, University of Manchester, Manchester, UK
2006-13 Lecturer, University of Manchester, Manchester, UK
2001-06 Junior Group Leader Max-Planck Institute of Immunobiology in Freiburg, Germany
2000-01 Postdoctoral Fellow, Max-Planck Institute of Immunobiology in Freiburg, Germany
1996 PhD, University of Genova, Italy and Institute of Molecular Pathology, Vienna, Austria
1989 Degree in Biological Sciences, University of Genoa, Italy
I did my PhD at King's College London in the Lab of Prof J.M. Littleton working on adaptive mechanisms underlying drug dependence. I demonstrated adaptive changes in the number of DHP sensitive VOCC following chronic exposure to central depressant drugs and showed that these changes were associated with genetic vulnerability to drug dependence.
I undertook post-doc training at the Clinical Research Centre Harrow, UK before joining the laboratory of Prof Nigel Holder at The Randall Institute, KCL and moving with him to UCL in 1998. Whilst at KCL and UCL I used zebrafish as a genetic model system for analysis of mechanisms underlying development.
Since 2000, I have been a Lecturer in Molecular Genetics in the School of Biological Sciences QMUL. Our work combines the two areas of my expertise: Molecular mechanisms underlying drug dependence and zebrafish as a developmental genetic model system. We have developed behavioural assays of drug seeking, compulsive drug seeking and relapse in zebrafish and are establishing lines of fish in which to explore the genetics contributing to these behaviours.