Has a bachelor's degree in Biological Sciences from the Universidade Santa Úrsula (2004), a Master's degree (2007) and PhD (2010) in Cellular and Molecular Biology from Fundação Oswaldo Cruz, with two periods as visiting scientist at the Departments of Pathology and Neuroscience of the Albert Einstein College of Medicine (Yeshiva University, New York, NY) With a post-doctoral degree from the Biophysics Institute (Federal University of Rio de Janeiro), under supervision of Prof. Rafael Linden (2010-2013).
Currently is Associate Researcher at the Oswaldo Cruz Foundation, where is investigating mechanisms of changes in embryonic development during congenital toxoplasmosis, with focus on the skeletal muscle system and Central Nervous System. In a model of mouse infection with Toxoplasma gondii investigates the effect that such infection causes to cerebral microcirculation and in the Blood-Brain Barrier, as a result of neuroinflammation. Has experience in Morphology, acting on the following subjects: parasite-host cell interaction, primary cell culture, cellular junctions, 2D and 3D cell culture models, Confocal and Transmission Electron Microscopy.
I obtained the Biology degree from the University of Sevilla in June 2008. For my PhD, I then joined Drs. Saló and Adell lab at the Genetics Department of the UB. Using the planarian S. mediterranea due to its amazing regenerative abilities, I demonstrated the role of specific signaling pathways in processes that allow regeneration of a proportioned body plan. I graduated with honors in Genetics in July 2014 and for my postdoctorate I decided to join Dr. Müller laboratory at the Max Planck Institute of Tübingen (Germany) in October 2014, to get an interdisciplinary training in Systems Biology and learn about Biophysics and computer modeling. In June 2015 I was awarded with an EMBO long-term postdoctoral fellowship. I studied how tissue patterns scale with embryo size using a quantitative biophysical in vivo approach. We described how embryos adjust tissue proportions to the changing size of their bodies. In June 2018 I decided to come back home and develop my independent research career in Sevilla (Spain), where I am currently working as an associate researcher at CABD (CSIC/UPO/JA). In February 2019 I obtained a Marie Skłodowska-Curie postdoctoral fellowship and in June 2019, a Junior Leader grant from Fundación Social La Caixa. Here I want to implement all my interdisciplinary acquired knowledge to study the complex formation of organs from a mechanical and patterning comprehensive perspective, using as an experimental paradigm the formation of the vertebrate eye.
Training: Dentistry, Biomedical Research, Bioengineering, Pathology
Postdoctoral: TGF-beta, wound healing, regeneration, radiation biology, light biology, stem cells, biomaterial, Lasers.
Current: Clinical translational research and molecular mechanism.
Positions: Past-President, NAALT; President-Elect WALT, Co-Chair SPIE, Chair, ASLMS
Interests: Signal Transduction, Lasers, Biological regulation, Photobiomodulation.
Researcher at the Population Genetics and Evolution group at i3S and invited assistant professor at the Faculty of Sciences of the University of Porto. Scientific topics include molecular basis of phenotype-genotype relationships, mechanisms underlying epistatic interactions under the compensatory mutation model, and the dynamics involved in the amino acid substitution at the protein structural level.
Professor of Biology at the University of Antwerp. Member of the Flemish Science Foundation review board. Editor of the journals Journal of Plant Research, Frontiers in Plant Science and PLOS ONE
--- CURRENT POSITION ---
CEO of neurochlore and B ATherapeutics
--- EDUCATION ---
° 1973-1979 - Post-doctoral & sabbatical studies: University of Cambridge (UK), University of Oslo (Norway) and McGill University (Canada)
° 1971 - Doctorat ès-sciences, Université de Paris VI (France)
° 1966 - B Sc. Biochemistry-Physiology, Hebrew University of Jerusalem (Israel)
--- AWARDS ---
° 2014 - Finalist Créa13 -Neurochlore
° 2013 - Award « Tremplins de La Provence » - Neurochlore
° 2012 - Award of the of the FNRS ( Fonds de la Recherche Scientifique de Belgique) of Belgium
° 2010 - Award of the European Society of Epilepsy
° 2009 - Award of the Grand Prix de la Recherche médicale de l'INSERM
° 2009 - Docteur Honoris causae, Liège University (Belgium)
° 2006 - Rotary Brain Research Award
° 2002 - The Health Price (Grand Prix de la Santé) of the Foundation of French Electricity ° 2000 - The American Epilepsy Society Research Award for outstanding research in epilepsies
1981-1985. Graduate Student, MRC Laboratory of Molecular Biology, Cambridge, U.K.
1985-1989. Postdoctoral Fellow Department of Biochemistry, University of California, Berkeley, CA.
1989-2000. Assistant and Associate Professor, Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT.
2000- Staff Scientist, Genomics Division, Lawrence Berkeley National Laboratory, Berkeley CA.
Professor of Developmental Biology in the Laboratory of Molecular Biology, Department of Plant Sciences, Wageningen University, The Netherlands.
Distinguished Scientist at Lawrence Berkeley National Laboratory, University Calif. Awards include ACS Medal of Honor, Lawrence Prize and Medal, Pezcollar-AACR Prize, Komen Foundation Brinker Award and Mina J. Bissell Award. More than 120 named and distinguished lectures. Past-President: American Soc. Cell Biology and Int. Society of Differentiation. Elected to the US National Academy, the IOM, American Philosophical Society, AAAS and the American Academy of Arts and Sciences
2013- Senior Lecturer, University of Manchester, Manchester, UK
2006-13 Lecturer, University of Manchester, Manchester, UK
2001-06 Junior Group Leader Max-Planck Institute of Immunobiology in Freiburg, Germany
2000-01 Postdoctoral Fellow, Max-Planck Institute of Immunobiology in Freiburg, Germany
1996 PhD, University of Genova, Italy and Institute of Molecular Pathology, Vienna, Austria
1989 Degree in Biological Sciences, University of Genoa, Italy
I did my PhD at King's College London in the Lab of Prof J.M. Littleton working on adaptive mechanisms underlying drug dependence. I demonstrated adaptive changes in the number of DHP sensitive VOCC following chronic exposure to central depressant drugs and showed that these changes were associated with genetic vulnerability to drug dependence.
I undertook post-doc training at the Clinical Research Centre Harrow, UK before joining the laboratory of Prof Nigel Holder at The Randall Institute, KCL and moving with him to UCL in 1998. Whilst at KCL and UCL I used zebrafish as a genetic model system for analysis of mechanisms underlying development.
Since 2000, I have been a Lecturer in Molecular Genetics in the School of Biological Sciences QMUL. Our work combines the two areas of my expertise: Molecular mechanisms underlying drug dependence and zebrafish as a developmental genetic model system. We have developed behavioural assays of drug seeking, compulsive drug seeking and relapse in zebrafish and are establishing lines of fish in which to explore the genetics contributing to these behaviours.
Titus Brown received his BA in Math from Reed College in 1997, and his PhD in Developmental Biology at Caltech in 2006. He has worked in digital evolution, climate measurements, molecular and evolutionary developmental biology, and both regulatory genomics and transcriptomics. His current focus is on using novel computer science data structures and algorithms to explore big sequencing data sets from metagenomics and transcriptomics.