Researching the assembly of cell surface appendages in archaea and their role in adhesion and biofilm formation. The model organism we study is the hyperthermophilic archaeon Sulfolobus acidocaldarius. We use genetic approaches to identify systems in Sulfolobus that are involved in the assembly of cell surface appendages and biochemically characterize the subunits and their interplay in the assembly process.
Research fields include translational research, invasion, metastasis, disseminated tumor cells, transcription, tumor-associated proteolysis, targeted therapy, micro-RNA, molecular staging of cancer. Associate Editor of the International Journal of Cancer, and on the Editorial Boards of: Advances in Medical Sciences, Journal of Cellular and Molecular Medicine, Frontiers in Molecular and Cellular Oncology, The Open Surgical Oncology Journal.
Assistant Professor in the Division of Infectious Diseases, Department of Medicine and Graduate Program in Molecular Virology and Microbiology, University of Pittsburgh School of Medicine. Co-Director of the Imaging Core of the Pittsburgh Center for HIV Protein Interactions.
Kathryn Ball trained as an enzymologist and protein biochemist. She was awarded a Broodbank Fellowship (University of Cambridge) and was the first CRUK Senior Cancer Research Fellow (University of Dundee). She moved to the University of Edinburgh in 2004 where she is the Professor of Biochemistry and Cell Signalling. Her current research is focused on protein structure function analysis and the mechanisms underlying the regulation of protein function by ubiquitin in human health and disease.
Senior Research Scientist, Food Nutrition & Health Team, AgResearch Limited. Based at the University of Auckland's Liggins Institute. Section Editor in "Nutrigenomics", European Journal of Nutrition.
Executive Director (Head) of the Institute fof Molecular Physiology and Biotechnology of Plants (IMBIO) at the Universtiy of Bonn. Editor in Chief of Planta. Member of EMBO
Isabel Bäurle is an Assistant Professor at the University of Potsdam, Germany. Her current interests range from transcriptional memory in response to environmental stress to transposon and RNA silencing. Having previously worked on plant stem cells and flowering time, she has a background in plant developmental genetics, molecular biology and epigenetics.
National Center for Immunization and Respiratory Diseases. Fellow of the American Academy of Microbiology.
Due to time constraints will only handle papers with primary focus (from a variety of angles) on the genus Streptococcus.
University of Missouri-KC, B.S., 1977-1982, Biology
University of Missouri-KC, M.S., 1982-1985, Staphylococcal genetics
University of KS Med Ctr. ,Ph.D.,1985-1990 Bacterial cell division
University of KS Med Ctr., Post-Doc,1990-1991 Bacillus septation
Emory University, Post-Doc, 1990-1993 Bacillus sporulation
Ph.D. Thesis: 1990. Cloning and characterization of the Bacillus subtilis homologs of the Escherichia coli cell division genes ftsZ and ftsA, and another gene affecting septation, dds. BW Beall. University of Kansas Medical Center, Department of Microbiology, Molecular Genetics and Immunology.
1990-1991: Postdoc, University of Kansas, Dept of Microbiology, Molecular Genetics, and Immunology.
1991-1993: Postdoc, Emory University, Dept. of Microbiology and Molecular Genetics.
1993-2004: Staff Scientist, Respiratory Diseases Branch, CDC/National Center for Immunization and Respiratory Diseases, Division of Bacterial Diseases, Respiratory Diseases Branch, Atlanta, GA
1/2005- present: Chief, Streptococcus Lab, CDC/National Center for Immunization and Respiratory Diseases, Division of Bacterial Diseases, Respiratory Diseases Branch, Atlanta, GA
Professor of Biology at the University of Antwerp. Member of the Flemish Science Foundation review board. Editor of the journals Journal of Plant Research, Frontiers in Plant Science and PLOS ONE
Regental Professor and Director of the Center for the Genetics of Host Defense at the UT Southwestern Medical Center in Dallas, Texas. Member of the National Academy of Sciences and the Institute of Medicine. Recipient of many awards, including the 2011 Nobel Prize for Medicine; the 2011 Shaw Prize; the 2009 Will Rogers Institute Annual Prize; the 2009 Albany Medical Center Prize; the 2007 Balzan Prize and the 2004 Robert Koch Prize. (Photo by Brian Coats for UT Southwestern Med Ctr)
1981-1985. Graduate Student, MRC Laboratory of Molecular Biology, Cambridge, U.K.
1985-1989. Postdoctoral Fellow Department of Biochemistry, University of California, Berkeley, CA.
1989-2000. Assistant and Associate Professor, Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT.
2000- Staff Scientist, Genomics Division, Lawrence Berkeley National Laboratory, Berkeley CA.
Group Leader at The Francis Crick Institute from April 2015. Programme Leader and Wellcome Trust Career Development Fellow at National Institute for Medical Research in London, UK from end of 2008. Previously, Royal Society Dorothy Hodgkin Fellow at King’s College London.