My group applies evolutionary genetics and genomic sciences to basic research on species evolution and translational research of infectious diseases. I have been studying infectious disease genomics since the early 2000's. At The Institute for Genomic Research (TIGR) I was part of the team that launched the field of parasite genomics, with work on several Plasmodium and trypanosomatid species, Theileria parva and Trichomonas vaginalis. At the Institute for Genome Sciences, University of Maryland School of Medicine, we have ongoing projects on a variety of parasites in the phylum Apicomplexa. These include the causative agents of malaria in humans (genus Plasmodium), tropical theileriosis and East Coast fever in cattle (genus Theileria), human babesiosis (genus Babesia), and human cryptosporidiosis (genus Cryptosporidium). Ongoing projects include the study of species biology and the nature of host-parasite interactions, based on the generation and analyses of genomes, and studies of vaccine efficacy and vaccine design, drug resistance and the evolution of parasite populations, informed by population genomics data. Our research is funded by NSF, NIH, USDA and the Bill and Melinda Gates Foundation.
BSc in Biochemistry from UCL London UK; PhD Cancer Virology at the Imperial Cancer Research Fund, London UK; post-doctoral fellowship at the European Molecular Biology Laboratory in Heidelberg, Germany, researching transcription; post-doctoral fellowship and assistant member of staff at the Ludwig Institute for Cancer Research in London, investigating a transcription factor network in Epstein-Barr virus and cell cycle regulation. Faculty School of Life Sciences at the University of Sussex, UK.
Dr. Singh received his B.Sc. from the Government Degree College Nahan, H.P. University, India and his M.Sc. and Ph.D from Devi Ahilya University, Indore, India. After a short stint as a Research Associate in the field of Trangenics of silkworm, Bombyx mori, in Indian Institute of Sciences (IISc.), Bangalore, India, Dr. Singh moved to Academic Sinica Taiwan to pursue post doctoral research in the field of eye development using Drosophila melanogaster model system. In 2002, Dr. Singh moved to Baylor College of Medicine, Houston, Texas to further pursue his work on Drosophila eye development and was promoted to an instructor (non-tenure track faculty) position in 2004. Dr. Singh was hired at University of Dayton as a tenure track assistant professor in 2007 and promoted to associate professor in 2013. To date, he has published one book and 52 papers.
Presently, I am working as a Senior Research Scientist at Memorial Sloan Kettering Cancer Center, New York, USA. My research interest includes “epigenetics and transcriptional regulation”. My research work is focused on exploring microenvironment of high-grade tumors arise in the overall course of the disease and in relation to treatment.
During 2021-22, I worked as Postdoctoral Research Scientist at Columbia University, New York, US. My work was to explore differences between regulatory networks involved in cancer and normal tissues using bioinformatics and computational biology. Earlier, I was working as Post-Doc at TAGC, INSERM, Aix Marseille University, Marseille, France during 2018-21. My research work was focused on the Identification of Epromoters, promoters showing enhancer activity, like clusters in various stress conditions. We have developed a pipeline to identify Epromoter like clusters. During 2016-18, I worked as Research Associate at CSIR-Institute of Genomics & Integrative Biology, New Delhi, India. My work was focused on the identification and validation of genetic and epigenetic biomarkers for high altitude phenotypes using bioinformatics approaches. I pursued my Ph.D. work at the Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, India, and earned my Ph.D. degree from NIU, India in 2016.
In my tenure, I have published around FIFTY Articles. In addition to this, I was awarded an Independent Research Project from the Indian Council of Medical Research, India. I was also an Invited Researcher (two times) at the Department of Medical Chemistry, Medical University of Vienna, Vienna, Austria. I was also awarded various travel grants from Indian and overseas funding agencies to present my research work.
A highly accomplished Computational Biologist and Bioinformatician with over 19 years of research expertise. My professional focus is on One Health bioinformatics, using pathogen transcriptomics and genomic surveillance to investigate and control infectious threats and antimicrobial resistance. My career has been marked by a strong track record of developing impactful tools and pipelines, including the Dlact antimicrobial resistance gene database and the Gen2Epi computational pipeline. Currently, as a Bioinformatician and Data Manager at the Vaccine and Infectious Disease Organization (VIDO), I apply my skills to analyze large-scale transcriptomics data and elucidate host-pathogen interactions in both human and animal populations
Experience
1978 -1987; Researcher in the Cancer Cell Chemistry Laboratory, Institute of Experimental and Clinical Medicine, Riga, Latvia.
Professor of Medical Biochemistry and Medical Genetics, University of Latvia, Faculty of Medicine (since 1998). Address: Jelgavas Street 1, Riga LV1004 Latvia. Chief of the Department of Medical Biochemistry (2011).
Leading researcher (since 2011) and Head of the Biochemistry Group, Department of Medicinal Chemistry, Latvian Institute of Organic Synthesis (since 1990).
1995 and 1997 “Red position” of CNRS 1993-1998; Institut Jacques Monod, Université Paris VII, Laboratoire de Biochimie de Différentiation, Paris, France.
Education:
Degree of Doctor of Biological Sciences (Dr. habil.), 1992, Institute of Experimental Medicine, St.-Petersburg, Russia. Degree of Candidate of Biological Sciences (Ph. D.), 1984, Cancer Research Centre, Moscow, Russia. Diploma with Distinction in Medical Biophysics, graduated from the Medico-Biological faculty of the 2nd Moscow Medical Institute, Moscow, Russia, 1978.
Kumar Somasundaram is a Professor at Department of Microbiology Cell Biology, Indian Institute of Science, Bangalore, India. He obtained his Veterinary Medicine degree (1985) from Madras Veterinary College, Masters in Biotechnology (1987) and Ph.D. in bacterial genetics (1993) from Madurai Kamaraj University, Madurai, India. Subsequently, he did his post-doctoral training at Northwestern University and University of Pennsylvania in Cancer Biology before moving to Indian Institute of Science (1999) as a faculty. The major focus of his laboratory is genetics of glioma, the most common primary adult cancer
Full professor at the Universidad Nacional Autónoma de México. Winner of several national conservation awards. Expert on microbial evolutionary ecology, works studying microbial mats and complex communities at Cuatro Ciénegas Coahuila, Mexico
A Regulatory Genomics group leader at Babraham Institute, Cambridge UK. Interested in the logic and robustness of gene regulation, with a particular focus on computational approaches and ageing as the experimental system.
For the past 20 years I have been actively working in the field of melanoma and naevi genomics. I have worked and performed my PhD candidature based at the QIMR Berghofer Medical Research Institute (1999-2015) and in 2015 I relocated as a Research Fellow in the Dermatology Research Centre, The University of Queensland Diamantina Institute. Over this time I have been working towards understanding the aetiology of melanoma, studying gene dysregulation during tumour progression along with predisposition to melanoma in families with high risk for melanoma development. My research group (genomics and miRNA biomarker discovery) based within the Dermatology Research Centre (UQDI) is currently engaged in miRNA biomarker and genomics research for early detection in melanoma, skin cancer (SCC), as well as non-small cell lung cancer.
TU Braunschweig & Uni Glasgow. Metagen Gesellschaft für Genomforschung mbH.
Max Planck Institute for Molecular Genetics. Altana Pharma AG. And currently Merck Healthcare KGaA
My speciality areas are Computational Biology, Systems Biology, Oncogenomics, Drug Target Identification, Biomarker Research.
Professor Tim Stinear is a Senior NHMRC Research Fellow and molecular microbiologist in the Department of Microbiology and Immunology at the Doherty Institute for Infection and Immunity, University of Melbourne, Australia. He leads a bacterial pathogenesis research lab that focuses on using comparative and functional genomics to understand how certain bacteria evolve, spread and cause disease. In particular, his team studies pathogenic mycobacteria and hospital superbugs Staphylococcus aureus (Golden Staph) and Vancomycin Resistant Enterococci (VRE). He received his PhD in Microbiology from Monash University in 2001 followed by a 3-year postdoctoral period at the Institut Pasteur, Paris. He is a fellow of the Australian Society for Microbiology.