Experience
1978 -1987; Researcher in the Cancer Cell Chemistry Laboratory, Institute of Experimental and Clinical Medicine, Riga, Latvia.
Professor of Medical Biochemistry and Medical Genetics, University of Latvia, Faculty of Medicine (since 1998). Address: Jelgavas Street 1, Riga LV1004 Latvia. Chief of the Department of Medical Biochemistry (2011).
Leading researcher (since 2011) and Head of the Biochemistry Group, Department of Medicinal Chemistry, Latvian Institute of Organic Synthesis (since 1990).
1995 and 1997 “Red position” of CNRS 1993-1998; Institut Jacques Monod, Université Paris VII, Laboratoire de Biochimie de Différentiation, Paris, France.
Education:
Degree of Doctor of Biological Sciences (Dr. habil.), 1992, Institute of Experimental Medicine, St.-Petersburg, Russia. Degree of Candidate of Biological Sciences (Ph. D.), 1984, Cancer Research Centre, Moscow, Russia. Diploma with Distinction in Medical Biophysics, graduated from the Medico-Biological faculty of the 2nd Moscow Medical Institute, Moscow, Russia, 1978.
I received my undergraduate education from the Massachusetts Institute of Technology (MIT) in 2004. Then, I pursued doctoral research in the Botstein laboratory at Princeton University, aiming to understand how cells coordinate their growth, gene expression, and metabolism. We discovered a simple mechanism that can account for the growth-rate dependent transcriptional responses across a wide range of growth conditions and growth rates. After defending my dissertation in 2010, I began a postdoctoral project in the van Oudenaarden laboratory at MIT, aiming to understand the Warburg effect, a hallmark of cancer cells characterized by the fermentation of glucose in the presence of enough oxygen to support respiration. This work demonstrated that aerobic glycolysis can reduce the energy demands associated with respiratory metabolism and stress survival and that, contrary to expectations and decades-long assumptions, exponential growth at a constant rate can represent not a single metabolic/physiological state but a continuum of changing states characterized by different metabolic fluxes. Following a lead from these experiments, we obtained direct evidence for differential stoichiometry among core ribosomal proteins in unperturbed wild-type cells. Our findings support the existence of ribosomes with distinct protein composition and physiological function that represent an explored layer of regulating gene expression.
Smith directed a research group at the Commissariat à l'énergie atomique (CEA) at Saclay, France (1989–1998) and then held the Chair of Computational Biohysics at he University of Heidelberg (1998-2012). His interests include high-performance computer simulation of biological macromolecules, neutron scattering in biology, the physics of proteins, enzyme catalysis, bioenergy and environmental biogeochemistry. As of 2012 Smith had published over 300 peer-reviewed scientific articles.
Prof. Sotelo-Mundo contributes as an academic editor in PeerJ, PeerJ Inorganic. Chemistry and PeerJ Materials Science. He holds a Ph.D. in Biochemistry from The University of Arizona (USA) with Prof. William Montfort. Back in Mexico in 1999 at Centro de Investigación en Alimentación y Desarrollo (http://www.ciad.mx), Dr. Sotelo-Mundo has contributed to the biochemistry and structural biology of proteins from marine invertebrates. Being at a food science institute has applied biochemistry to food science and technology. Also, he collaborates in the materials science graduate program at Universidad de Sonora as a visiting professor, participating in research about macrocyclic biomimetic molecules. His research focuses on the structure and function of proteins related to disease, and the chemical structure of natural and synthetic molecules related to biomedical applications. The experimental approach is the crystallography of proteins and small molecules, along with biochemical and biophysical techniques. Our group collaborates with a range of groups from disciplines from genomics and metagenomics, biochemistry, supramolecular chemistry, and material sciences. PubMed http://goo.gl/uW67bK ResearchGate http://goo.gl/llPHxI and Publons https://publons.com/researcher/1220970/rogerio-sotelo-mundo/
Senior scientist, Host-Microbe Interactions, The New Zealand Institute for Plant and Food Research.
Dr. Xiaotian Tang is now an assistant professor (ZJU100 Young Professor) at Zhejiang University. He was a postdoctoral associate at Yale School of Medicine. His research interests include vector-borne diseases of animals and plants, and arthropod-pathogen-host interactions. He is also interested in evolutionary biology of arthropods.
He has over 40 publications in high-quality peer-reviewed journals, including Cell, PLOS Biology, eLife, Cell Reports, and Science Translational Medicine. He has served as academic or review editor for 4 journals and reviewer for over 20 journals.
Professor of Chemistry, and Director of the Program in Bioinformatics, Boston University. Elected Fellow of the AAAS. Recipient of the Herbert A. Sober Award of the ASBMB. Research interests include developing new chemical probe methods (in particular, hydroxyl radical footprinting) for determining the structure of DNA, RNA, and DNA-protein complexes.
Professor of Molecular Biology, Head of the Laboratory of Structural Dynamics, Stability and Folding of Proteins of the Institute of Cytology, Russian Academy of Science.
Professor at the Department of Molecular Medicine of University of South Florida, College of Medicine, and Visiting Professor at Moscow Institute of Physics and Technology.
I received my B.S. and M.S. degrees in Physics from Leningrad State University in Russia in 1986, then, completed Ph.D. and Doctor of Sciences (D.Sc.) degrees in Physics and Mathematics (field of study - Biophysics) at the Moscow Institute of Physics and Technology (1991) and the Institute Experimental and Theoretical Biophysics of the Russian Academy of Sciences (1998), respectively. I spent early career working on protein folding at Institute of Protein Research and the Institute for Biological Instrumentation (Russia). In 1998, I moved to the University of California Santa Cruz to study protein folding, misfolding, protein conformation diseases, and protein intrinsic disorder phenomenon. In 2004, I was invited to join the Indiana University School of Medicine to primary work on the intrinsically disordered proteins. Since 2010, I am with USF, where I continue to study intrinsically disordered proteins and analyze protein folding and misfolding processes.
I have authored over 950 scientific publications. I am an editor of several scientific journals and edited a number of books and book series on protein structure, function, folding, and misfolding. Since 2014, I am included by the Thomson Reuters to the Clarivate list of Highly Cited Researchers™.
Senior Molecular Biologist (CR1 CNRS) at the Interdisciplinary Research Institute (IRI) - Lille 1 University - France.
My lab studies how human genes can be turned on and off by transcription factors. We investigate the fundamental mechanisms underlying specific gene control in the context of diseases, such as cancer.
Prof. Marcus Vieira is the Bioengineering and Biomechanics Laboratory head at Universidade Federal de Goiás. He received BS in Electrical Engineering and Physical Education from the Universidade Federal de Goiás, and MSc and PhD in Biomedical Engineering from the Universidade de São Paulo. He focuses his research in computational neuroscience and biomechanics, especially in motoneuron modeling, spinal CPG, nonlinear tools for movement variability analysis, including entropy, fractal dimension and recurrence analysis, coherence analysis in postural control, transitory tasks such as gait initiation, and gait dynamic stability.
Dr. Ranjit Vijayan obtained his PhD in Life Sciences Interface/Biochemistry from the University of Oxford, UK, and his DipGrad in Management from the London School of Economics & Political Science, University of London, UK. In 2004 Dr Vijayan obtained his MSc in Computer Science from the University of Wales, Aberystwyth, UK, and prior to this his BEng in Electrical & Electronic Engineering, Nanyang Technological University, Singapore.
Dr. Vijayan's research interests include; molecular dynamics simulations of biological macromolecules, protein structure modeling, structure based drug discovery, genomics & transcriptomics, pharmacogenomics and high-performance computing.