• PeerJ Journals
    • PeerJ Publishing
    • PeerJ – Life & Environment
      • About the journal Sections
      • Aquatic Biology
      • Biochemistry, Biophysics and Molecular Biology
      • Biodiversity and Conservation
      • Bioinformatics and Genomics
      • Brain and Cognition
      • Ecology
      • Environmental Science
      • Microbiology
      • Paleontology and Evolutionary Science
      • Plant Biology
      • Zoological Science
    • PeerJ Computer Science
    • PeerJ Physical Chemistry
    • PeerJ Organic Chemistry
    • PeerJ Inorganic Chemistry
    • PeerJ Analytical Chemistry
    • PeerJ Materials Science
    • Visit PeerJ.org and get involved
  • About
    • PeerJ Journals Overview
    • PeerJ Journals FAQ
    • What we publish
    • 8 Years publishing
    • Solutions for authors
    • Reputation
    • High quality peer review
    • Fast publishing
    • Indexing and Impact Factor
    • Global readership
    • Feature comparison
    • Reduced cost publishing
    • Author feedback
    • Early career researcher benefits
    • Senior researcher benefits
    • Open review (optional)
    • Rebuttal letters
  • About
    • PeerJ Journals Overview
    • PeerJ Journals FAQ
    • What we publish
    • 8 Years publishing
    • Solutions for authors
    • Reputation
    • High quality peer review
    • Fast publishing
    • Indexing and Impact Factor
    • Global readership
    • Feature comparison
    • Reduced cost publishing
    • Author feedback
    • Early career researcher benefits
    • Senior researcher benefits
    • Open review (optional)
    • Rebuttal letters
  • More
    • Job listings and more
    • Post a new job or collaboration
    • Latest researcher questions
    • Post a research question
    • Subjects
    • Search articles
      • Peer-reviewed Journals
      • PeerJ (Life, Biological, Environmental and Health Sciences)
      • PeerJ Computer Science
      • PeerJ Physical Chemistry
      • PeerJ Organic Chemistry
      • PeerJ Inorganic Chemistry
      • PeerJ Analytical Chemistry
      • PeerJ Materials Science
      • Preprints
      • PeerJ Preprints
    • Table of contents
      • Table of Contents - current and archives
      • PeerJ - Medicine articles
      • PeerJ - Biology & Life science articles
      • PeerJ - Environmental Science articles
      • PeerJ - General bio (stats, legal, policy, edu)
      • PeerJ Computer Science
      • PeerJ Preprints
    • Academic advisors
    • Volunteer to review
    • Collections
    • Blog
    • Prepaid Publishing
    • Reviews and awards
    • Spread the word
    • Who are we?
    • Contact
  • Login
    • AUTHORS
      • Peer Journals Overview
      • Submission Guidelines
      • Subject Areas
      • Editorial Board
      • Editorial Criteria
      • Pricing
      • Help Center
      • General FAQ
      • Computer Science FAQ
      • Aims and Scope
      • Author Interviews
      • Policies and Procedures
    • SUBMIT ARTICLE
    WANT A PROFILE LIKE THIS?
    Create my FREE Plan Or learn about other options
    Nikolai Slavov
    PeerJ Editor & Author
    210 Points

    Contributions by role

    PeerJ PrePrints author 210

    Contributions by subject area

    Cell-Biology 210
    Computational-Biology 105
    Molecular-Biology 105
    Biochemistry 105
    Bioengineering 105
    Genomics 105
    Biotechnology 70
    Developmental-Biology 35

    Nikolai Slavov

    PeerJ Editor & Author

    Summary

    I received my undergraduate education from the Massachusetts Institute of Technology (MIT) in 2004. Then, I pursued doctoral research in the Botstein laboratory at Princeton University, aiming to understand how cells coordinate their growth, gene expression, and metabolism. We discovered a simple mechanism that can account for the growth-rate dependent transcriptional responses across a wide range of growth conditions and growth rates. After defending my dissertation in 2010, I began a postdoctoral project in the van Oudenaarden laboratory at MIT, aiming to understand the Warburg effect, a hallmark of cancer cells characterized by the fermentation of glucose in the presence of enough oxygen to support respiration. This work demonstrated that aerobic glycolysis can reduce the energy demands associated with respiratory metabolism and stress survival and that, contrary to expectations and decades-long assumptions, exponential growth at a constant rate can represent not a single metabolic/physiological state but a continuum of changing states characterized by different metabolic fluxes. Following a lead from these experiments, we obtained direct evidence for differential stoichiometry among core ribosomal proteins in unperturbed wild-type cells. Our findings support the existence of ribosomes with distinct protein composition and physiological function that represent an explored layer of regulating gene expression.

    Biochemistry Biophysics Cell Biology Computational Biology Developmental Biology Genetics Genomics Molecular Biology

    Editing Journals

    PeerJ - the Journal of Life & Environmental Sciences

    Past or current institution affiliations

    Northeastern University

    Work details

    Slavov Laboratory

    Northeastern University
    September 2015
    Bioengineering

    Websites

    • Google Scholar
    • ORCID
    • LinkedIn
    • Slavov Lab

    PeerJ Contributions

    • Preprints 5
    June 18, 2018 - Version: 2
    Transformative opportunities for single-cell proteomics
    1,263 downloads
    2,223 views
    Harrison Specht, Nikolai Slavov
    bioengineering
    biotechnology
    cell-biology
    computational-biology
    genomics
    https://doi.org/10.7287/peerj.preprints.26821v2
    June 15, 2018 - Version: 1
    Ribosome stoichiometry: from form to function.
    783 downloads
    949 views
    Edward P Emmott, Marko Jovanovic, Nikolai Slavov
    biochemistry
    cell-biology
    molecular-biology
    https://doi.org/10.7287/peerj.preprints.26991v1
    May 28, 2018 - Version: 1
    Single cell protein analysis for systems biology
    1,105 downloads
    881 views
    Ezra Levy, Nikolai Slavov
    cell-biology
    molecular-biology
    https://doi.org/10.7287/peerj.preprints.26965v1
    January 31, 2017 - Version: 1
    Mass-spectrometry of single mammalian cells quantifies proteome heterogeneity during cell differentiation
    764 downloads
    1,030 views
    Bogdan Budnik, Ezra Levy, Nikolai Slavov
    biochemistry
    cell-biology
    computational-biology
    developmental-biology
    molecular-biology
    https://doi.org/10.7287/peerj.preprints.2767v1
    November 14, 2015 - Version: 1
    From differential transcription of ribosomal proteins to differential structure of ribosomes
    415 downloads
    851 views
    Nikolai Slavov
    biochemistry
    bioengineering
    cell-biology
    genomics
    https://doi.org/10.7287/peerj.preprints.1504v1
    About us - PeerJ team | Our publications | Benefits | Partnerships | Endorsements Awards
    Resources - FAQ | Careers | Press room | Terms of use | Privacy | Contact
    Academic boards - Advisors | Editors | Subject areas
    Follow us - PeerJ blog | Twitter | Facebook | LinkedIn | Instagram | Pinterest
    Submission guides - PeerJ – Life and Environment | PeerJ Computer Science | PeerJ Chemistry
    Spread the word - Activities | Resources
     
    PeerJ feeds - Atom | RSS 1.0 | RSS 2.0 | JSON
    PeerJ Computer Science feeds - Atom | RSS 1.0 | RSS 2.0 | JSON
    Archives - PeerJ – Life and Environment | PeerJ Computer Science
    ©2012-2021 PeerJ, Inc | Public user content licensed CC BY 4.0 unless otherwise specified.
    PeerJ ISSN: 2167-8359 PeerJ Comput. Sci. ISSN: 2376-5992 PeerJ Preprints ISSN: 2167-9843