Advisory Board and Editors Computational Biology
Katsuhiko Shirahige
Professor, Laboratory of Genome Structure and Function, Institute of Molecular and Cellular Biosciences, The University of Tokyo.
Director of Research Center for Epigenetic Disease, The University of Tokyo
Himanshu Singh
Presently, I am working as a Senior Research Scientist at Memorial Sloan Kettering Cancer Center, New York, USA. My research interest includes “epigenetics and transcriptional regulation”. My research work is focused on exploring microenvironment of high-grade tumors arise in the overall course of the disease and in relation to treatment.
During 2021-22, I worked as Postdoctoral Research Scientist at Columbia University, New York, US. My work was to explore differences between regulatory networks involved in cancer and normal tissues using bioinformatics and computational biology. Earlier, I was working as Post-Doc at TAGC, INSERM, Aix Marseille University, Marseille, France during 2018-21. My research work was focused on the Identification of Epromoters, promoters showing enhancer activity, like clusters in various stress conditions. We have developed a pipeline to identify Epromoter like clusters. During 2016-18, I worked as Research Associate at CSIR-Institute of Genomics & Integrative Biology, New Delhi, India. My work was focused on the identification and validation of genetic and epigenetic biomarkers for high altitude phenotypes using bioinformatics approaches. I pursued my Ph.D. work at the Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, India, and earned my Ph.D. degree from NIU, India in 2016.
In my tenure, I have published around FIFTY Articles. In addition to this, I was awarded an Independent Research Project from the Indian Council of Medical Research, India. I was also an Invited Researcher (two times) at the Department of Medical Chemistry, Medical University of Vienna, Vienna, Austria. I was also awarded various travel grants from Indian and overseas funding agencies to present my research work.
Reema Singh
A highly accomplished Computational Biologist and Bioinformatician with over 19 years of research expertise. My professional focus is on One Health bioinformatics, using pathogen transcriptomics and genomic surveillance to investigate and control infectious threats and antimicrobial resistance. My career has been marked by a strong track record of developing impactful tools and pipelines, including the Dlact antimicrobial resistance gene database and the Gen2Epi computational pipeline. Currently, as a Bioinformatician and Data Manager at the Vaccine and Infectious Disease Organization (VIDO), I apply my skills to analyze large-scale transcriptomics data and elucidate host-pathogen interactions in both human and animal populations
Nikolai Slavov
I received my undergraduate education from the Massachusetts Institute of Technology (MIT) in 2004. Then, I pursued doctoral research in the Botstein laboratory at Princeton University, aiming to understand how cells coordinate their growth, gene expression, and metabolism. We discovered a simple mechanism that can account for the growth-rate dependent transcriptional responses across a wide range of growth conditions and growth rates. After defending my dissertation in 2010, I began a postdoctoral project in the van Oudenaarden laboratory at MIT, aiming to understand the Warburg effect, a hallmark of cancer cells characterized by the fermentation of glucose in the presence of enough oxygen to support respiration. This work demonstrated that aerobic glycolysis can reduce the energy demands associated with respiratory metabolism and stress survival and that, contrary to expectations and decades-long assumptions, exponential growth at a constant rate can represent not a single metabolic/physiological state but a continuum of changing states characterized by different metabolic fluxes. Following a lead from these experiments, we obtained direct evidence for differential stoichiometry among core ribosomal proteins in unperturbed wild-type cells. Our findings support the existence of ribosomes with distinct protein composition and physiological function that represent an explored layer of regulating gene expression.
Jeremy C. Smith
Smith directed a research group at the Commissariat à l'énergie atomique (CEA) at Saclay, France (1989–1998) and then held the Chair of Computational Biohysics at he University of Heidelberg (1998-2012). His interests include high-performance computer simulation of biological macromolecules, neutron scattering in biology, the physics of proteins, enzyme catalysis, bioenergy and environmental biogeochemistry. As of 2012 Smith had published over 300 peer-reviewed scientific articles.
Othman Soufan
Assistant Professor, Alley Heaps Associate, Computer Science Department, St. Francis Xavier University. The Soufan Lab aims to advance life sciences by developing innovative methods, systems and resources for targeted knowledge discovery from biological data.
Mikhail Spivakov
A Regulatory Genomics group leader at Babraham Institute, Cambridge UK. Interested in the logic and robustness of gene regulation, with a particular focus on computational approaches and ageing as the experimental system.
Eike Staub
TU Braunschweig & Uni Glasgow. Metagen Gesellschaft für Genomforschung mbH.
Max Planck Institute for Molecular Genetics. Altana Pharma AG. And currently Merck Healthcare KGaA
My speciality areas are Computational Biology, Systems Biology, Oncogenomics, Drug Target Identification, Biomarker Research.
Hong-Wei Sun
Chief, Biodata Mining and Discovery Section, OST, IRP, NIAMS, NIH
Twenty years of experience in Bioinformatics since post-doc at Yale, where I solved the x-ray crystal structure of a cytokine (MIF). Developed and implemented in recent years a significant number of NGS data analysis pipelines and methods with emphasis on ChIP-Seq, ATAC-Seq, RNA-Seq, scATAC-Seq, scRNA-Seq, Enhancers & Super Enhancers, and AI/ML. Co-authored more than 60 NGS data-based publications since 2010, including 33 in high impact journals such as Nature, Science, Cell, Nature Immunology, Science Immunology, Nature Cell Biology, Nature Structural Biology, Immunity, Molecular Cell, and PNAS. A founding member of four Bioinformatics groups. Co-author of two published Java programs. Also a co-author of a Medical Bioinformatics textbook and a co-inventor of nine issued patents.
Leila Taher
Leila Taher received her Ph.D. in Natural Sciences from the University of Bielefeld, Germany, in 2006. After postdoctoral training at the Instituto Miguel Lillo (2006-2007) in Tucumán, Argentina, and at the National Institutes of Health (2008-2012) in the USA, she returned to Germany, where she started her own research group on computational modelling of transcriptional regulation at the University of Rostock. Since 2015 she is an assistant professor at the University of Erlangen-Nuremberg.
Gian Gaetano Tartaglia
* October 2014 - ICREA Research Professor * May 2010 - Group Leader, Bioinformatics and Genomics Program, Centre for Genomic Regulation, Barcelona (Spain) * November 2011 - Clare Hall Life Member, University of Cambridge (UK) * 2005-2010 - Postdoctoral Fellow, Clare Hall College, Chemistry Department, University of Cambridge (UK) * 2001-2005 - PhD, Biochemistry Department, University of Zurich, Zurich (CH) * 1996-2000 - MPhil Theoretical Physics, Statistical Mechanics, University la Sapienza, Rome (Italy)
Tatiana V Tatarinova
Fletcher Jones Endowed Chair in Computational Biology and Associate Professor of Biology, University of La Verne. Member of The Russian-American Science Association Coordinating Committee.