Disorder of a derived mechanism of nervous system functions, capable to have evolved, provides a testable explanation for age-related neurodegeneration
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Abstract
By viewing memories as first-person internal sensations, it was possible to derive a potential mechanism of nervous system functions. Accordingly, a spectrum inter-postsynaptic functional LINKs (IPLs) are the key structural changes responsible for encoding learning-changes in physiological time-scales of milliseconds that can be retained for variable lengths of time. The inter-spine interaction that lead to the formation of IPLs was examined for its feasibility to have evolved through the simple steps of variation and selection. A stage of significant spine and neuronal loss during the early stages of development indicates that a corresponding stage of IPL fusion that led to neuronal loss during evolution. In the surviving cells is expected that a mechanism for stabilizing IPLs for the rest of life was triggered. This sequence of events can be achieved if the initial stage of transient inter-neuronal inter-spine fusion can trigger the lifelong expression of specific proteins that can stabilize the intermediate stage of inter-spine hemifusion. This is supported by the presence of proteins within the spines that arrest fusion between the spines. Since IPL mechanisms are expected to be utilized during every event of learning, any defect in the continued expression of proteins that stabilizes IPLs at the stage of hemifusion can lead to age-related neurodegeneration.
Cite this as
2019. Disorder of a derived mechanism of nervous system functions, capable to have evolved, provides a testable explanation for age-related neurodegeneration. PeerJ Preprints 7:e27458v2 https://doi.org/10.7287/peerj.preprints.27458v2Author comment
One of the expected changes was corrected from variation to adaptation. Furthermore, article is re-written to emphasize age-related neurodegeneration as a consequence of failure in this adaptive change. Several new references were added. One figure is changed to provide a clear explanation.
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Competing Interests
U.S. patent 9477924 pertains to an electronic circuit model of the interpostsynaptic functional LINK
Author Contributions
Kunjumon I Vadakkan conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft.
Patent Disclosures
The following patent dependencies were disclosed by the authors:
U.S. patent 9477924 dated 25th October 2016.
Data Deposition
The following information was supplied regarding data availability:
There is no data collected for the work.
Funding
The author received no funding for this work.
