PeerJ PrePrints

Publishing rapid scientific communication and early findings

Aromatase, which is a rate-limiting enzyme that catalyzes the conversion of androgen to estrogen, plays an essential role in the development of estrogen-dependent breast cancer. Side effects due to aromatase inhibitors (AIs) necessitate the pursuit of novel inhibitor...

["Bioinformatics","Computational Biology","Drugs and Devices","Pharmacology"]

Differential scanning fluorimetry (DSF) is used widely as a thermal shift assay to study protein stability and protein-ligand interactions. The benefit of DSF is that it is simple, cheap and can generate melting curves in 96-well plates providing good throughput....


The fight against the emergence of mutant influenza strains has led to the screening of an increasing number of compounds for inhibitory activity against influenza neuraminidase. This study explores the chemical space of neuraminidase inhibitors (NAIs), which provides...

["Bioinformatics","Computational Biology","Drugs and Devices","Computational Science"]

In the present research, I used an open access data set (Medicinal Genomics) consisting of nearly 200'000 genome-wide single nucleotide polymorphisms (SNPs) typed in 28 cannabis accessions to shed light on the plant's underlying genetic structure. Genome-wide loadings...

["Agricultural Science","Evolutionary Studies","Genomics","Plant Science","Taxonomy"]

In July 2014, we observed premature feather loss (PFL) among non-sibling, common tern Sterna hirundo chicks between 2 and 4 weeks of age at Gull Island in northern Lake Ontario, Canada. Rarely observed in wild birds, to our knowledge PFL has not been recorded in...

["Ecology","Marine Biology","Toxicology","Virology","Public Health"]

The fan shell P. nobilis (Linnaeus, 1758) is the largest marine bivalve in the Mediterranean Sea which acts as ecosystem engineer, offering an adequate substratum to several associated benthic species. P. nobilis is threatened by the reduction and loss of its natural...

["Biodiversity","Conservation Biology","Ecology","Marine Biology"]

We make a first attempt at distinguishing information-carrying visual signal by comparing visual characteristics of American Sign Language and everyday human motion, to identify what clues might be available in one but not in the other. The comparison indicated...

["Computational Biology"]

Age and growth information is essential for accurate stock assessment of fish, and growth model selection may influence the result of stock assessment. Previous descriptions of the age and growth of elasmobranches relied mainly on the von Bertalanffy growth model...

["Aquaculture, Fisheries and Fish Science"]

The use of notation and concepts from mathematical set theory is investigated as a method for describing species concepts, and potentially higher level taxa. These methods may facilitate the easy databasing of species concepts, allowing the concepts themselves...


Remane’s Artenminimum (“species minimum”) concept was developed for the Baltic Sea, the world’s largest semi-enclosed brackish water body with a unique permanent salinity gradient. It argues that taxonomic diversity of macrobenthic organisms is lowest within the...

["Biodiversity","Ecology","Environmental Sciences","Microbiology"]

In the present work, I perform direct numerical simulations of pulsatile flow through a 75% eccentric stenosis using the Lattice Boltzmann Method. The stenosis was studied by Varghese et al. (2007b) in a benchmark computation and the goal of this work is to validate...

["Computational Biology","Neurology","Computational Science"]

The “Pedra de Fogo” Formation dated from the Permian period (approximately 280 million years ago), belongs to the sedimentary Parnaiba Basin, located in the northeastern region of Brazil. It is recognized by their well preserved fossil contents and it is notable...

["Biodiversity","Paleontology","Plant Science"]

The growing number of wildlife endocrinology studies have greatly enhanced our understanding of comparative endocrinology, and have also generated extensive longitudinal data for a vast number of species. However, the extensive graphical analysis required for these...

["Biodiversity","Computational Biology","Diabetes and Endocrinology"]

Under models of isolation-by-distance, population structure is determined by the probability of identity-by-descent between pairs of genes according to the geographic distance between them. Well established analytical results indicate that the relationship between...

["Computational Biology","Evolutionary Studies","Genetics","Mathematical Biology"]

​Sibutramine has a mechanism of action similar to that of antidepressants used as analgesics (like duloxetine). Limited data exists regarding the analgesic action of sibutramine. We tested increasing doses of p.o. sibutramine (0.1, 0.5, 1.5, 5.0 mg/kg) in the writhing...

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A PeerJ PrePrint is a draft of an article, abstract, or poster that has not yet been peer reviewed for formal publication. Submit a draft, incomplete, or final version of your work for free.

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Rapid scientific communication & early findings

A PeerJ 'PrePrint' is a draft that has not yet been peer reviewed for formal publication. Similar to preprint servers that already exist (for example, authors can submit draft, incomplete, or final versions of articles they are working on.

By using this service, authors establish precedent; they can solicit feedback, and they can work on revisions of their manuscript. Once they are ready, they can submit their PrePrint manuscript into the peer reviewed PeerJ journal (although it is not a requirement to do so).

Submissions today can be approved by editorial staff and online within 24 hours.

PeerJ PrePrints is fully CC-BY, meaning you don't need to worry about sharing or reusing articles you find. Everyone benefits. Learn more about CC-BY.