PeerJ PrePrints - where science is heading

25 downloads
179 views

Changes in hardware or image processing settings are a common issue for large multi-center studies. In order to pool MRI data acquired under these changed conditions, it is necessary to demonstrate that the changes do not affect MRI-based measurements. In these...

["Bioinformatics","Neurology","Radiology and Medical Imaging","Statistics"]
doi:10.7287/peerj.preprints.808v2

Sustained oscillations are frequently observed in biological systems consisting of a negative feedback loop, but a mathematical model with two ordinary differential equations (ODE) that has a negative feedback loop structure fails to produce sustained oscillations....

["Biophysics","Computational Biology","Mathematical Biology"]
doi:10.7287/peerj.preprints.1272v1

We bring together fifteen, nonredundant, tabulated collections (amounting to 696 separate measurements) of the apparent permeability (Papp) of Caco-2 cells to marketed drugs. While in some cases there are some significant interlaboratory disparities, most are quite...

["Computational Biology","Pharmacology"]
doi:10.7287/peerj.preprints.1271v1
64 downloads
223 views

Valveless, tubular pumps are widespread in the animal kingdom, but the mechanism by which these pumps generate fluid flow are often in dispute. Where the pumping mechanism of many organs was once described as peristalsis, other mechanisms, such as dynamic suction...

["Bioengineering","Biophysics","Computational Biology","Developmental Biology","Mathematical Biology"]
doi:10.7287/peerj.preprints.906v2
3 downloads
21 views

The current focus from research based pharmaceutical companies is rather on cancer, not CNS. There are several reasons for this, e.g. problems with pre-clinical models, problems with dose-finding, large long-lasting trials, high failure rate, eventually leading...

["Clinical Trials","Neurology"]
doi:10.7287/peerj.preprints.1270v1
10 downloads
53 views

Nitrogen (N) and Carbon (C) are popular indicators of soil fertility; however, they are not soil fertility itself. In fact, they may be seen as just two aspects of the one entity. Soil microbial biomass (SMB) is also one of soil fertility indicators; furthermore,...

["Agricultural Science","Microbiology","Soil Science"]
doi:10.7287/peerj.preprints.1217v2
10 downloads
100 views

Background. It is widely assumed that the uterine cavity in non-pregnant women is a sterile body environment under physiological conditions. We have previously shown that some women with overt dysbiosis of the vaginal microbiome, present with a polymicrobial Gardnerella...

["Microbiology","Molecular Biology","Gynecology and Obstetrics","Women's Health"]
doi:10.7287/peerj.preprints.1269v1
6 downloads
37 views

In the United States, state-specific mortality rates that are high relative to national rates can result from legitimate reasons or from variability in coding practices. This paper identifies instances of state-specific mortality rates that were at least twice...

["Epidemiology"]
doi:10.7287/peerj.preprints.1268v1
52 downloads
198 views

Introduction: The determinant factors that influence self-reported quality of vision have yet to be fully elucidated. This study evaluated a range of contextual information, established psychophysical tests, and in particular, a series of cognitive tests as potentially...

["Epidemiology","Ophthalmology","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.738v2
4 downloads
41 views

Two Component Systems and Phosphorelays (TCS/PR) are environmental signal transduction cascades in prokaryotes and, less frequently, in eukaryotes. The internal domain organization of proteins and the topology of TCS/PR cascades play an important role in shaping...

["Bioinformatics","Computational Biology","Mathematical Biology","Synthetic Biology"]
doi:10.7287/peerj.preprints.1267v1
219 downloads
440 views

Traditionally, programmers have received a wide range of training on programming languages and methodologies, but rarely about software energy consumption. Yet, the popularity of mobile devices and cloud computing require increased awareness about software energy...

["Software Engineering"]
doi:10.7287/peerj.preprints.886v2
41 downloads
417 views

Background: The p-curve is a plot of the distribution of p-values below .05 reported in a set of scientific studies. It has been used to estimate the frequency of bias in the selection of variables and analyses for publication, p-hacking. A recent study by Head...

["Statistics"]
doi:10.7287/peerj.preprints.1266v1
5 downloads
90 views

Electroencephalography (EEG) signals’ interpretation is based on waveform analysis, where meaningful information should emerge from a plethora of data. Nonetheless, the continuous increase in computational power and the development of new data processing algorithms...

["Bioengineering","Bioinformatics","Biophysics","Neuroscience","Neurology"]
doi:10.7287/peerj.preprints.1265v1
1 download
34 views

Ladyfish (Elops sp) are a common and economically valuable coastal nearshore species found along coastal beaches, bays, and estuaries of the southeastern United States, and subtropical and tropical regions worldwide. Previously, ladyfish were a substantial bycatch...

["Aquaculture, Fisheries and Fish Science","Biodiversity","Conservation Biology","Ecology","Marine Biology"]
doi:10.7287/peerj.preprints.1264v1
14 downloads
36 views

Rapidly changing climate makes humans realize that there is a critical need to rethink the current conservation and incorporate climate change adaptation into conservation planning. Whether Great Bustards’ (Otis tarda dybowskii), a globally endangered species whose...

["Biodiversity","Biogeography","Conservation Biology","Ecology","Zoology"]
doi:10.7287/peerj.preprints.1263v1

The right way forward for science

Not all preprint venues are truly open-access. In contrast, PeerJ PrePrints is fully CC-BY, meaning you don't need to worry about sharing or reusing articles you find. Everyone benefits. Learn more about CC-BY.

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Rapid scientific communication & early findings

A PeerJ 'PrePrint' is a draft that has not yet been peer reviewed for formal publication. Similar to preprint servers that already exist (for example arXiv.org), authors can submit draft, incomplete, or final versions of articles they are working on.

By using this service, authors establish precedent; they can solicit feedback, and they can work on revisions of their manuscript. Once they are ready, they can submit their PrePrint manuscript into the peer reviewed PeerJ journal (although it is not a requirement to do so).

Submissions today can be approved by editorial staff and online within 24 hours.