Actin’ between phase separated domains for heterochromatin repair
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Abstract
DNA double-strand breaks (DSBs) are particularly challenging to repair in pericentromeric heterochromatin because of the increased risk of aberrant recombination in highly repetitive sequences. Recent studies have identified specialized mechanisms enabling ‘safe’ homologous recombination (HR) repair in heterochromatin. These include striking nuclear actin filaments (F-actin) and myosins that drive the directed motion of repair sites to the nuclear periphery for ‘safe' repair. Here, we summarize our current understanding of the mechanisms involved, and propose how they might operate in the context of a phase-separated environment.
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2019. Actin’ between phase separated domains for heterochromatin repair. PeerJ Preprints 7:e27824v1 https://doi.org/10.7287/peerj.preprints.27824v1Author comment
This is a review submitted to a peer reviewed journal
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Competing Interests
The authors declare no competing interests.
Author Contributions
Chetan C Rawal contributed reagents/materials/analysis tools, prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft, wrote the first draft.
Christopher P Caridi conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, approved the final draft.
Irene Chiolo conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft.
Data Deposition
The following information was supplied regarding data availability:
Not yet available.
Funding
This work was supported by NIH R01GM117376 and NSF Career 1751197 to I.C. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
