In silico analysis of miR-137 transcription inhibition in homozygous (T/T) schizophrenic patients: a pilot study.
Author and article information
Abstract
MicroRNA miR-137 single nucleotide polymorphism (rs1625579 SNP) is strongly associated with the worsening of schizophrenia symptoms and is involved in miR-137 gene suppression. MicroRNA miR-137 regulates synaptogenesis, neural plasticity and suppresses a variety of cancertypes. Based on in silico predictions of the current MIR137 Host Gene with and without the SNP, it can be hypothesized that the mutation reversibly inhibits miR-137 gene transcription by steric hindrance due to an alteration on DNA conformation, stability, electrostatic potential, and transcription factor binding sites.
Cite this as
2019. In silico analysis of miR-137 transcription inhibition in homozygous (T/T) schizophrenic patients: a pilot study. PeerJ Preprints 7:e27560v1 https://doi.org/10.7287/peerj.preprints.27560v1Author comment
This is a preprint submission to PeerJ Preprints.
Sections
Supplemental Information
MIR137HG SEQUENCE (GRCH38.P7) OBTAINED FROM THE SINGLE NUCLEOTIDE POLYMORPHISM DATABASE (DBSNP) WITH CODE RS1625579 SNP
Figure 1: The miR-137 gene inserted in MIR137HG and the distance in base pair of it from the SNP.
Figure 2: Comparison of DNA stability between wild (G) and mutant (T) sequences.
Figure 3: (a) Promotor region prediction. (b) Comparison of DNA parameters between wild and mutant sequences.
Additional Information
Competing Interests
The authors declare that they have no competing interests.
Author Contributions
Stephany C Esmaile conceived and designed the experiments, performed the experiments, prepared figures and/or tables, authored or reviewed drafts of the paper.
Bruno G Sousa performed the experiments, prepared figures and/or tables.
Carlos A G Blaha conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, approved the final draft.
Jonas I N Oliveira analyzed the data, contributed reagents/materials/analysis tools, authored or reviewed drafts of the paper, approved the final draft.
Data Deposition
The following information was supplied regarding data availability:
The MirR137HG sequence obtained from the Single Nucleotide Polymorphism Database without and within polymorphism G/T are provided in the supplementary file.
Funding
This work was partially financed by the Brazilian Research Agencies CAPES and CNPq. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
