On a general definition of the set of native conformations for globular polypeptides
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Abstract
Here we question the generality of the conventional definition of a native conformation –as the 3-dimensional conformation of an entire globular polypeptide molecule. Although considered common knowledge, and thus not explicitly stated in modern writings, this definition of native conformations has a history as old as the protein folding problem. We attempt a more applicable definition that better correlates with functional activity and thus may be a more suitable substitute for the current convention.
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2016. On a general definition of the set of native conformations for globular polypeptides. PeerJ PrePrints 4:e1735v1 https://doi.org/10.7287/peerj.preprints.1735v1Author comment
We question the generality of the conventional definition of a native conformation and attempt a more applicable definition.
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Competing Interests
The author declares that they have no competing interests.
Author Contributions
Imadol V Jeff-Eke conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper, none.
Data Deposition
The following information was supplied regarding data availability:
The research in this article did not generate any raw data.
Funding
The author received no funding for this work.
