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Here we question the generality of the conventional definition of a native conformation –as the 3-dimensional conformation of an entire globular polypeptide molecule. Although considered common knowledge, and thus not explicitly stated in modern writings, this definition of native conformations has a history as old as the protein folding problem. We attempt a more applicable definition that better correlates with functional activity and thus may be a more suitable substitute for the current convention.
We question the generality of the conventional definition of a native conformation and attempt a more applicable definition.