Motion and morphometry in clinical populations
Author and article information
Abstract
Introduction The relationship between participant motion, demographic variables and MRI-derived morphometric estimates was investigated in autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD) and schizophrenia. Participant motion was estimated using resting state fMRI and used as a proxy measure for motion during T1-weighted MRI acquired in the same session. Analyses were carried out in scans qualitatively assessed as free from motion-related artifact.
Methods Whole brain T1-weighted MRI and resting state fMRI acquisitions from the ABIDE, ADHD-200 and COBRE databases were included in our analyses. Motion was estimated using coregistration of sequential resting state volumes. Morphometric estimates were obtained using Freesurfer v5.3. We investigated if motion is related to diagnosis, age and gender, and scanning site. We further determined if there is a relationship between participant motion and cortical thickness, contrast, and volumetric estimates.
Results 2131 participants were included in our analyses. Participant motion was higher in all clinical groups compared with healthy controls. Younger (age < 20 years) and older (age > 40 years) people move more than individuals aged 20 – 40 years. Increased motion is associated with reduced average cortical thickness (-0.02 mm thickness per mm motion, p = 4.03×10-5) and cortical contrast (0.95% contrast reduction per mm motion, p = 5.25×10-11) in scans that have been qualitatively assessed as free from motion artifact.
Conclusions Participant motion is increased in clinical groups and is systematically associated with morphometric estimates. These findings indicate that accounting for participant motion may be important for improving the statistical validity of morphometric studies.
Cite this as
2015. Motion and morphometry in clinical populations. PeerJ PrePrints 3:e1363v1 https://doi.org/10.7287/peerj.preprints.1363v1Author comment
This paper describes our investigation of participant motion during acquisition in autism spectrum disorder, attention deficit hyperactivity disorder, and schizophrenia, and how this motion is related to estimates of cortical thickness, contrast and subcortical volumes.
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Supplemental Information
Supplementary material: acquisition parameters for ABIDE and ADHD-200 rsfMRI acquisitions
Table 1. Summary of rsfMRI acquisition parameters for ABIDE and ADHD-200 studies
Supplementary material: effect size and p-values for relationship between participant motion and volumetric estimates
Table 2. Summary of relationship between participant motion and volumetric estimates. Rows marked with an * indicate volume estimates with p < 0.05 when using scans qualitatively free from motion artifact. Rows marked with † indicate brain regions with p < 0.05 when using scans that have not undergone QA, but p > 0.05 following visual QA assessment
Additional Information
Competing Interests
The authors declare that they have no competing interests.
Author Contributions
Heath R Pardoe conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.
Rebecca Kucharsky Hiess performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, reviewed drafts of the paper.
Ruben Kuzniecky performed the experiments, contributed reagents/materials/analysis tools, reviewed drafts of the paper.
Data Deposition
The following information was supplied regarding data availability:
https://sites.google.com/site/hpardoe/motion
Funding
This study was supported by an Amazon Web Services in Education grant. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
