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Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Shaobin Gu conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Ying Wu performed the experiments, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Jianbo Yang conceived and designed the experiments.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

Kunming specific pathogen-free mice were provided by the Henan Laboratory Animal Center. License number: SCXK (Yu) 2005-0001.The present study was conducted in accordance with the principles outlined in the National Institutes of Health Guide for the Care and Use of Laboratory Animals.


This work was supported by Foundation for University Key Teacher by Henan Province (Grant No. 2014GGJS-056) and National Natural Science Foundation of China (Grant No. U1304307). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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