Comparison of radiomics-based machine-learning classifiers for the pretreatment prediction of pathologic complete response to neoadjuvant therapy in breast cancer

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Background

Methods

Study population and data collection

MRI acquisition information

Image postprocessing

Image annotation and segmentation

Radiomic feature extraction

Feature selection and model building

Machine learning classifiers

Statistical analysis

Results

Patient information and pathological features

Performance of the radiomic models with machine learning classifiers

Subgroup analysis of radiomics model performance for predicting pCR in TN and luminal breast cancer

Discussion

Limitations

Conclusion

Supplemental Information

Radiomic features

DOI: 10.7717/peerj.17683/supp-1

Additional Information and Declarations

Competing Interests

The authors declare there are no competing interests.

Author Contributions

Xue Li conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables, and approved the final draft.

Chunmei Li performed the experiments, analyzed the data, prepared figures and/or tables, and approved the final draft.

Hong Wang performed the experiments, prepared figures and/or tables, and approved the final draft.

Lei Jiang performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Min Chen conceived and designed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Data Availability

The following information was supplied regarding data availability:

The Duke-Breast-Cancer-MRI dataset is available at The Cancer Imaging Archive (TCIA): https://www.cancerimagingarchive.net/collection/duke-breast-cancer-mri/.

Funding

The authors received no funding for this work.

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