Lung–brain ‘cross-talk’: systemic propagation of cytokines in the ARDS via the bloodstream using a blood transfusion model does not influence cerebral inflammatory response in pigs

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Biochemistry, Biophysics and Molecular Biology

Main article text

 

Introduction

Materials and Methods

Anaesthesia and instrumentation

Experimental design

Postmortem analysis

Statistics

Results

Discussion

Conclusions

Supplemental Information

ARRIVE protocol.

DOI: 10.7717/peerj.13024/supp-2

Additional Information and Declarations

Competing Interests

Erik Hartmann is an Academic Editor for PeerJ.

Author Contributions

René Rissel analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the paper, and approved the final draft.

Moritz Schaefer performed the experiments, prepared figures and/or tables, and approved the final draft.

Jens Kamuf performed the experiments, authored or reviewed drafts of the paper, and approved the final draft.

Robert Ruemmler performed the experiments, authored or reviewed drafts of the paper, and approved the final draft.

Julian Riedel analyzed the data, authored or reviewed drafts of the paper, and approved the final draft.

Katja Mohnke analyzed the data, authored or reviewed drafts of the paper, and approved the final draft.

Miriam Renz analyzed the data, authored or reviewed drafts of the paper, and approved the final draft.

Erik K. Hartmann conceived and designed the experiments, performed the experiments, prepared figures and/or tables, authored or reviewed drafts of the paper, and approved the final draft.

Alexander Ziebart conceived and designed the experiments, performed the experiments, prepared figures and/or tables, authored or reviewed drafts of the paper, and approved the final draft.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

This prospective randomised animal study was conducted after approval by the State and Institutional Animal Care Committee (reference number: 23 177-07/G 14-1-084).

Data Availability

The following information was supplied regarding data availability:

The statistical analysis of the histological samples from the cortex and the hippocampus and all labor measurements are available in the Supplemental Files.

Funding

The study was funded by a fellowship from the Mainz Research School of Translational Biomedicine (TransMed) affiliated with Johannes Gutenberg-University, Mainz, Germany. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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