Association of heat shock protein polymorphisms with patient susceptibility to coronary artery disease comorbid depression and anxiety in a Chinese population

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Brain, Cognition and Mental Health

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Introduction

Materials & Methods

Subjects

SNP selection and Genotyping

Statistical analysis

Results

Characteristics of the study participants

Association between gene polymorphisms and CAD risk

Haplotype Analysis

Influence of gene polymorphisms on the risk of depression/anxiety in CAD patients

Discussion

Conclusions

Supplemental Information

Additional Information and Declarations

Competing Interests

The authors declare there are no competing interests.

Author Contributions

Haidong Wang analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the paper, and approved the final draft.

Yudong Ba analyzed the data, prepared figures and/or tables, and approved the final draft.

Wenxiu Han and Haixia Zhang performed the experiments, authored or reviewed drafts of the paper, and approved the final draft.

Laiqing Zhu conceived and designed the experiments, prepared figures and/or tables, and approved the final draft.

Pei Jiang conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the paper, and approved the final draft.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

This study was carried out in accordance with the recommendations of the medical ethics committee of Jining First People’s Hospital guidelines with written informed consent from all subjects. All subjects gave written informed consents and the protocol was approved by the medical ethics committee of the Jining First People’s Hospital (JY2016062).

Data Availability

The following information was supplied regarding data availability:

The raw data are available in the Supplemental File.

Funding

This work was supported by the National Natural Science Foundation of China (grant number 81602846), the Chinese Society of Clinical Pharmacy Project of Wu Jieping Medical Foundation (grant number 320.6750.19090-8), the Taishan Scholar Project of Shandong Province (grant number tsqn201812159), The Key Research and Development Program of Jining Science and Technology (2019SMNS012) and the Scientific Research Development Fundation of Kangda College of Nanjing Medical University (KD2020KYJJYB044). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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