Groups, groupoids, and information sources: models of mitochondrial deterioration and aging
Division of Epidemiology, New York State Psychiatric Institute, New York, New York, United States
- Subject Areas
- Mathematical Biology, Cognitive Disorders, Epidemiology, Neurology, Psychiatry and Psychology
- aging, cognition, protein structure, rate distortion
- © 2014 Wallace
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ PrePrints) and either DOI or URL of the article must be cited.
- Cite this article
- 2014. Groups, groupoids, and information sources: models of mitochondrial deterioration and aging. PeerJ PrePrints 2:e381v1 https://doi.org/10.7287/peerj.preprints.381v1
Using mitochondrial free energy delivery rate as a temperature analog, we examine the 'spontaneous symmetry breaking' of the group associated with the error minimization coding scheme related to protein folding, and characterize the phase transition that drives the collapse of normal folding to pathological amyloid production. Similarly, groupoids prove central to the study of analogous, often highly punctuated, 'ground state' failures in far more complex biological processes, adopting Maturana's perspective on the central role of cognition throughout the living state.