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Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Onofre Orozco López conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, performed the computation work.

Carlos Eduardo Castañeda Hernández conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables.

Agustín Rodríguez Herrero conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables.

Gema García Saéz contributed reagents/materials/analysis tools, reviewed drafts of the paper.

María Elena Hernando contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Patent Disclosures

The following patent dependencies were disclosed by the authors:

Matlab Trade Mark and Simulink Trade Mark

Data Deposition

The following information was supplied regarding data availability:

For ethical reasons to maintain confidentiality is not possible to publish the data of real type 1 diabetes mellitus patient.

Funding

This work was supported by CONACYT (México) under scholarship number 284966 and to retention program 120489. The authors also thanks to University Center of los Lagos, University of Guadalajara by the support under project 227509 from program PROINPEP-2015-DCYT. Also this work was partly supported by the Spanish FIS grant from the Ministry of Health and Consumer Affairs ``FIT-CLOOP''- FIS PI14/00109, co-funded by FEDER and by a mobility grant from CIBER. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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