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Supplemental Information

Supplemental Table 1: Lists of yeast and human complexes predicted through complex to interactome alignment.

This table contains four sheets with the following contents: HC yeast predictions - Prediction of yeast complexes by aligning human complexes to the yeast interactome (high-confidence predictions). All yeast predictions - Prediction of yeast complexes by aligning human complexes to the yeast interactome (all predictions). HC human predictions - Prediction of human complexes by aligning yeast complexes to the human interactome (high-confidence predictions). All human predictions - Prediction of human complexes by aligning yeast complexes to the human interactome (all predictions). #QCC/#TCC: number of query/target complex components; only significant GO terms are shown; those GO terms that also belong to the set of most abundant significant GO terms of the given query complex are highlighted in capitals; complexes are sorted by homogeneity, followed by the fraction and number of new components compared to all known complexes in the target species; new components are shown in lower case.

DOI: 10.7287/peerj.preprints.280v2/supp-1

Supplemental Table 2: Lists of fly complexes predicted through aligning human and yeast complexes to the fly interactome.

This table contains four sheets with the following contents: HC predictions from human - Prediction of fly complexes by aligning human complexes to the fly interactome (high-confidence predictions). All predictions from human - Prediction of fly complexes by aligning human complexes to the fly interactome (all predictions). HC predictions from yeast - Prediction of fly complexes by aligning yeast complexes to the fly interactome (high-confidence predictions). All predictions from yeast - Prediction of fly complexes by aligning yeast complexes to the fly interactome (all predictions). #QCC/#TCC: number of query/target complex components; only significant GO terms are shown; those GO terms that also belong to the set of most abundant significant GO terms of the given query complex are highlighted in capitals; complexes are sorted by homogeneity, followed by the fraction and number of new components compared to all known fly complexes; new components are shown in lower case.

DOI: 10.7287/peerj.preprints.280v2/supp-2

Supplemental Table 3: Lists of human, fly and yeast complexes predicted through aligning mycoplasma complexes to the given species interactome.

This table contains six sheets with the following contents: HC predictions in human - Prediction of human complexes by aligning mycoplasma complexes to the human interactome (high-confidence predictions). All predictions in human - Prediction of human complexes by aligning mycoplasma complexes to the human interactome (all predictions). HC predictions in fly - Prediction of fly complexes by aligning mycoplasma complexes to the fly interactome (high-confidence predictions). All predictions in fly - Prediction of fly complexes by aligning mycoplasma complexes to the fly interactome (all predictions). HC predictions in yeast - Prediction of yeast complexes by aligning mycoplasma complexes to the yeast interactome (high-confidence predictions). All predictions in yeast - Prediction of yeast complexes by aligning mycoplasma complexes to the yeast interactome (all predictions). #QCC/#TCC: number of query/target complex components; only significant GO terms are shown; those GO terms that also belong to the set of most abundant significant GO terms of the given query complex are highlighted in capitals; complexes are sorted by homogeneity, followed by the fraction and number of new components compared to all known complexes in the target species; new components are shown in lower case.

DOI: 10.7287/peerj.preprints.280v2/supp-3

Additional Information

Competing Interests

There are no competing interests.

Author Contributions

Roland Pache conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Patrick Aloy conceived and designed the experiments, analyzed the data, reviewed drafts of the paper.

Grant Disclosures

The following grant information was disclosed by the authors:

Spanish Ministerio de Ciencia e Innovación:

PSE-010000-2009-1; BIO2010-22073

Funding

This work was partially supported by the Spanish Ministerio de Ciencia e Innovación (PSE-010000-2009-1; BIO2010-22073). RAP is a recipient of the Spanish FPU fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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