Internal sensation of pleasure can be explained as a specific conformation of semblance: Inference from electrophysiological findings
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Abstract
Semblance hypothesis was able to find a solution for the generation of first- person internal sensation of memory along with provisions for behavioral motor actions. The derived inter-postsynaptic functional LINK (IPL) mechanism was able to explain a large number of findings from different levels of the system ranging from perception to sleep. It was possible to explain long-term potentiation (LTP) as the effect of experimental scaling-up of the changes occurring during natural learning. By keeping the latter relationship as a baseline, it was possible to explain long-term depression (LTD) observed in the nucleus accumbens (NAc), a scaled-up change of a mechanism responsible for inducing internal sensation of pleasure. This mechanism provides inter-connectable explanations for the attenuation of postsynaptic potentials, reduced ring of medium spiny neurons and the finding that LTD induced by stimulation of one pathway to NAc occludes the LTD induction by another pathway.
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2019. Internal sensation of pleasure can be explained as a specific conformation of semblance: Inference from electrophysiological findings. PeerJ Preprints 7:e27886v1 https://doi.org/10.7287/peerj.preprints.27886v1Author comment
This is a preprint version of the article. This article was not published anywhere before in journals or conferences.
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Competing Interests
U.S. patent 9477924 pertains to an electronic circuit model of the inter-postsynaptic functional LINK.
Author Contributions
Kunjumon Vadakkan conceived and designed the experiments, prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft.
Patent Disclosures
The following patent dependencies were disclosed by the authors:
U.S. patent 9477924 pertains to an electronic circuit model of the inter-postsynaptic functional LINK.
Data Deposition
The following information was supplied regarding data availability:
No raw data or code is used for the work.
Funding
The author received no funding for this work.
