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The relationship between air pollution and public health has gained increasing attention in the past decade. Many time-series analyses have been conducted worldwide, including in all the major cities of the United States, Europe, and Asia. However, the most current time-series analysis study of Ontario, Canada dates back to 2012 and includes only a single city, calling the need of a more recent study at a provincial scale. As a result, we propose to conduct time-series analyses of major Ontario cities and then use a hierarchical model to pool the results and construct a dose-response relationship and generate a predictive regression.