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Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Oliwia Zegrocka-Stendel conceived and designed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Krzysztof Bojakowski conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Małgorzata Dutkiewicz conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Iwona Grabowska conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Gabriela Janusz performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Magdalena Kowalewska conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Katarzyna Koziak conceived and designed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Mariusz Gruza conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Kamil Jatczak performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Katarzyna Filip conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Piotr Cmoch conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Marta Łaszcz performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Grzegorz Grynkiewicz conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

The Bioethics Commission of Medical University of Warsaw (No. 46/2012)

Patent Disclosures

The following patent dependencies were disclosed by the authors:

Protoescigenin derivative, process of its preparation, use of said compound and pharmaceutical composition comprising that compound (EP 15000566.8)

Animal model for the Parkes Weber syndrome (EP14001527.2)

Data Deposition

The following information was supplied regarding data availability:

The research in this article did not generate any raw data.

Funding

This work was supported by the European Union under the Operational Programme “Innovative Economy” grant no. POIG.01.01.02-14-072/09 entitled “Search of innovative endothelial drug in a group of new escin derivatives”. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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