Bioinformatics computation of metabolic models from sequenced genomes
- Published
- Accepted
- Subject Areas
- Bioinformatics, Biotechnology, Computational Biology, Genomics, Synthetic Biology
- Keywords
- genomics, systems biology, bioinformatics, human genome project, gene finding, protein function, reactome inference, metabolic maps, metabolic model, gap filling
- Copyright
- © 2015 Karp et al.
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ PrePrints) and either DOI or URL of the article must be cited.
- Cite this article
- 2015. Bioinformatics computation of metabolic models from sequenced genomes. PeerJ PrePrints 3:e1501v1 https://doi.org/10.7287/peerj.preprints.1501v1
Abstract
In the early days of the human genome project (HGP), during the late 1980s and early 1990s, there was skepticism that the genome project would produce biologically meaningful information. The reality is that bioinformatics has allowed us to extract far more biology from sequenced genomes than any published predictions in the early 1990s. Thanks to the efforts of many researchers in several subfields of bioinformatics, we can now process a sequenced genome through a series of computations to produce a quantitative metabolic flux model. Thus, surprisingly, bioinformatics has achieved what might have been held up as a holy grail of the field, before the goal was even articulated.
Author Comment
A Perspective Article we have submitted elsewhere without success, in finished form 2015/03/20. Precedes three somewhat related articles that have appeared recently:
• http://msb.embopress.org/content/11/10/831 (2015/10/14)
• http://www.nature.com/news/human-genome-project-twenty-five-years-of-big-biology-1.18436 (2015/09/30)
• http://www.biomedcentral.com/1741-7007/13/79 (2015/09/23)