Divergent relationship of circulating CTRP3 levels between obesity and gender: a cross-sectional study

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Introduction

Methods

Ethics statement

Study design and participants

Clinical and laboratory measurements

Statistical analysis

Results and Discussion

Study population

Relationship between CTRP3 and categorical variables

Relationship between CTRP3 and continuous variables

Study limitations and conclusion

Supplemental Information

Spreadsheet containing absolute values for each subject

Column A: Subject ID number; Column B: CTRP3 concentration; Column C: subject age; Column D: subject gender; Column E: description for clinical symptom which necessitated the heart catheterization; Column F-M: heart catheterization results; Column N: Was the subject a smoker; Column O: Did the subject have a previous bout of symptoms requiring heart catheterization; Column P: was the subject previously diagnosed with Dyslipidemia; Column Q-T: Values from blood lipid panel (mg/dL); Column U: was the subject previously diagnosed with Hypertension; Column V: blood glucose values (mg/dL); Column W: was the subject previously diagnosed with Type 2 Diabetes Mellitus; Column X: is the subject considered obese?; Column X: subject’s body mass index.

DOI: 10.7717/peerj.2573/supp-1

Additional Information and Declarations

Competing Interests

The authors declare there are no competing interests.

Author Contributions

Roy Marshal Wagner performed the experiments, analyzed the data, wrote the paper, reviewed drafts of the paper.

Kamesh Sivagnanam performed the experiments, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

William Andrew Clark conceived and designed the experiments, analyzed the data, reviewed drafts of the paper.

Jonathan M. Peterson conceived and designed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

All study subjects provided written informed consent for the study procedures. The study was approved by the Institutional Review Board of East Tennessee State University’s Office of Research and Sponsored Programs (IRB #0313-35s, 2013, ETSU/VA Medical IRB Board).

Data Availability

The following information was supplied regarding data availability:

The raw data has been supplied as a Data S1.

Funding

This research was supported in part National Institute On Alcohol Abuse And Alcoholism of the National Institutes of Health under Award Number R03AA023612, by the National Institutes of Health Award Number C06RR0306551, East Tennessee State University Research Development Committee (E82262), and College of Clinical & Rehabilitative Health Sciences, ETSU, Dean’s Student Research Grant. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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