Correlation and mediation analysis between plasmapheresis donation behavior and bone mineral density and bone metabolism biomarkers: a cross-sectional study based on plasmapheresis donors at high risk of osteoporosis in China

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Biochemistry, Biophysics and Molecular Biology

Main article text

 

Introduction

Methods

Study design and participants

Sample size estimation

Blood sampling and information collection

Laboratory analysis and assays

Study outcome parameters

Statistical analysis

Quality control

Results

Baseline characteristics

Effects of different donation behavior indicators on bone metabolism biomarkers

Multiple linear regression analysis on bone metabolism biomarkers

Nonlinear trends between indicators of plasmapheresis donation behaviors and bone metabolism biomarkers

Baseline comparison and mediation analysis of SF

Analysis related to BMD

Discussion

Supplemental Information

Comparison of ferritin and iron accumulation rates between two groups of plasma donors

DOI: 10.7717/peerj.18589/supp-1

Correlation between plasmapheresis behavior, SF and bone metabolism markers (r)

DOI: 10.7717/peerj.18589/supp-2

Multiple linear regression analysis of BMD in different sites

DOI: 10.7717/peerj.18589/supp-3

Multiple linear regression of 25OHD

DOI: 10.7717/peerj.18589/supp-4

Process for inclusion and exclusion of subjects

DOI: 10.7717/peerj.18589/supp-5

STROBE checklist

DOI: 10.7717/peerj.18589/supp-6

Additional Information and Declarations

Competing Interests

Hui Yang & Zhiwei Li are employed by Nanyue Biopharming Co., Ltd. and Yating Yang, Shouqiang Yang & Yuan He are employed by Sichuan Yuanda Shuyang Pharmaceutical Co., Ltd. They declare the following on the conflict of interest: They promise to avoid conflicts of interest (even superficial conflicts) with the company, its shareholders and its customers.

Author Contributions

Wan Li analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Jia Liu conceived and designed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Changqing Li performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Hui Yang performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Yating Yang performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Zhiwei Li performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Shouqiang Yang performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Yuan He performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Guanglin Xiao conceived and designed the experiments, analyzed the data, authored or reviewed drafts of the article, and approved the final draft.

Ya Wang conceived and designed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Yongjun Chen conceived and designed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

This study passed the review of the Ethics Committee of the Institute of Blood Transfusion, Chinese Academy of Medical Sciences (approval number: NO: 2022029).

Data Availability

The following information was supplied regarding data availability:

The raw measurements are available in the Supplementary Files.

Funding

This work was supported by CAMS Innovation Fund for Medical Sciences (CIFMS), Grant Number: 2021-I2M-1-060. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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