The fall of the mycobacterial cell wall: interrogating peptidoglycan synthesis for novel anti-TB agents

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Biochemistry, Biophysics and Molecular Biology

Main article text

 

Introduction

Survey Methodology

Synthesis of peptidoglycan

Mur ligase inhibitors for combating TB

Inhibitors of MurC

Inhibitors of MurD

Inhibitors of MurE

Inhibitors of MurF

Multitarget inhibitors

Targeting ATP-binding site

UDP-substrate binding

Tetrahedral intermediate mimics

Arresting the catalytic activity

Inhibitors of MurX

Inhibitors of MurG & MurJ

Polymerisation and crosslinking

Conclusions

Additional Information and Declarations

Competing Interests

The authors declare there are no competing interests.

Author Contributions

Cheng-Yu Chiang conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Nicholas P. West conceived and designed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Data Availability

The following information was supplied regarding data availability:

This is a literature review.

Funding

Cheng-Yu Chiang is a recipient of a University of Queensland Graduate School Scholarship for Higher Degree Research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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