Clinical dosage of lidocaine does not impact the biomedical outcome of sepsis-induced acute respiratory distress syndrome in a porcine model

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Main article text

 

Introduction

Materials and Methods

Anesthesia & instrumentation

Sepsis induction

Study protocol

  • 1) Lidocaine intravenous (n = 8): 2 mg kg−1 h−1 for 1 h, followed by 1 mg kg−1 h−1

  • 2) Lidocaine inhalative (n = 8): 2 mg kg−1 h−1 for 1 h, followed by 1 mg kg−1 h−1

  • 3) Sham group (n = 8): NaCl 0.9%, 5 ml/h i.v. continuously.

Post mortem analysis

Statistics

Results

Hemodynamics

Respiratory

Laboratory

Post mortem analysis

Discussion

Conclusion

Supplemental Information

Lidocaine in ARDS Dataset.

DOI: 10.7717/peerj.15875/supp-1

Additional Information and Declarations

Competing Interests

Erik K. Hartmann is an Academic Editor for PeerJ.

Author Contributions

René Rissel analyzed the data, prepared figures and/or tables, authored and approved the final draft.

Christian Moellmann conceived and designed the experiments, performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Victoria Albertsmeier performed the experiments, prepared figures and/or tables, and approved the final draft.

Miriam Renz analyzed the data, authored or reviewed drafts of the article, and approved the final draft.

Robert Ruemmler analyzed the data, authored or reviewed drafts of the article, and approved the final draft.

Jens Kamuf performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Erik K. Hartmann conceived and designed the experiments, performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Alexander Ziebart conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

The State and Institutional Animal Care Committee (Rhineland-Palatinate, Koblenz, Germany) approved the study (ID G16-1-015).

Data Availability

The following information was supplied regarding data availability:

Raw data are available in a Supplemental File.

Funding

The authors received no funding for this work.

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