Association between human leukocyte antigen (HLA) and end-stage renal disease (ESRD): a meta-analysis

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Introduction

Material and Methods

Search strategy

Selection/study characteristics

Data extraction

Methodological quality assessment

Statistical analysis

Results

Characteristics and quality of studies included

Association of HLA B*50 and HLA B*40 with ESRD

Association of HLA DRB*12 and DRB*13 with ESRD

Association of HLA DQB1*6 and DQA1*3 with ESRD

Discussion

Supplemental Information

PRISMA checklist

DOI: 10.7717/peerj.14792/supp-1

Funnel plot for HLA-B*40 allele

DOI: 10.7717/peerj.14792/supp-2

Funnel plot for HLA-B*50 allele

DOI: 10.7717/peerj.14792/supp-3

Funnel plot for HLA-DRB1*12 allele

DOI: 10.7717/peerj.14792/supp-4

Funnel plot for HLA-DRB1*13 allele

DOI: 10.7717/peerj.14792/supp-5

Funnel plot for HLA-DQB1*6 allele

DOI: 10.7717/peerj.14792/supp-6

Funnel plot for HLA-DQB1*3 allele

DOI: 10.7717/peerj.14792/supp-7

Meta-analysis Rationale

DOI: 10.7717/peerj.14792/supp-8

Characteristics of eligible case-control studies included in this meta-analysis

DOI: 10.7717/peerj.14792/supp-9

Additional Information and Declarations

Competing Interests

The authors declare there are no competing interests.

Author Contributions

Naila Noureen performed the experiments, analyzed the data, prepared figures and/or tables, and approved the final draft.

Nousheen Zaidi conceived and designed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Data Availability

The following information was supplied regarding data availability:

The PubMed search terms used: (“HLA” OR “human leukocyte antigen”) AND (“polymorphism” OR “alleles” OR “variant” OR “genotype”) AND (‘kidney transplantation’ OR ‘renal transplantation’ OR ‘kidney graft’ OR ‘kidney transplant’ OR ‘renal transplant’ OR ‘end stage renal disease’ OR ‘renal replacement therapy’ OR dialysis OR hemodialysis OR ‘peritoneal dialysis’ OR ‘hemodialysis patient’ OR ‘ESRD’ OR ‘end-stage-renal-disease’).

Funding

The authors received no funding for this work.

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