Genetic variants of IFIH1 and DHX58 affect the chronicity of hepatitis C in the Chinese Han population

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Genetic variants of IFIH1 and DHX58 affect the chronicity of hepatitis C in the Chinese Han population Read the full article https://t.co/QgUvhtzyFE #Genomics #Epidemiology #Gastroenterology
Genetic variants of IFIH1 and DHX58 affect the chronicity of hepatitis C in the Chinese Han population Read the full article https://t.co/PKzsAGn37x #Genomics #Epidemiology #Gastroenterology
Biochemistry, Biophysics and Molecular Biology

Main article text

 

Introduction

Materials & Methods

Study participants

Data and blood sample collection

SNP selection and genotyping

Statistical analysis

Results

Demographic and clinical characteristics of participants

Association of candidate genes polymorphisms with HCV chronicity

Stratified analysis

Bioinformatics analysis of IFIH1-DHX58 SNPs

Discussion

Conclusions

Supplemental Information

Codebook for raw data

DOI: 10.7717/peerj.14740/supp-2

Primers sequences of selected SNPs in IFIH1 and DHX58 gene

MAF and PHWE were calculating from 554 East Asian population in 1000 Genomic Project using PLINK (v.1.90).

DOI: 10.7717/peerj.14740/supp-3

Associations of IFIH1-DHX58 SNPs with HCV infection outcomes in dominant and additive models of multivariable analyses

PFDR is expressed as the P value after multiple corrections by the FDR method

DOI: 10.7717/peerj.14740/supp-4

Interaction of rs2074158& rs10930046 with serum AST level

DOI: 10.7717/peerj.14740/supp-5

Allele frequencies of studied SNPs in different populations from the NCBI dbSNP database

DOI: 10.7717/peerj.14740/supp-6

Additional Information and Declarations

Competing Interests

The authors declare there are no competing interests.

Author Contributions

Peng Huang analyzed the data, authored or reviewed drafts of the article, and approved the final draft.

Jing-Jing Wu performed the experiments, prepared figures and/or tables, and approved the final draft.

Jin-Wei Zhang performed the experiments, prepared figures and/or tables, and approved the final draft.

Yu-Qing Hou analyzed the data, authored or reviewed drafts of the article, and approved the final draft.

Ping Zhu conceived and designed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Rong Yin conceived and designed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Rong-Bin Yu conceived and designed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Yun Zhang conceived and designed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Ming Yue conceived and designed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Wei Hou conceived and designed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

This study was approved by the Ethics Committee of Nanjing Medical University (2017445).

Data Availability

The following information was supplied regarding data availability:

Raw data is available in the Supplemental Files.

Funding

All external funding or support received during this research was from the Open Research Fund Program of the State Key Laboratory of Virology of China (2021KF008) (PH), the Outstanding Youth Fund Project of Jiangsu Province (BK20190126), the Natural Science Foundation of Yunnan Province (2019FA005) (PH), and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD). There was no additional external funding received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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