Ann V. Hedrick

Academic Editor on

September 1, 2025

Estimating density of native carnivores in central Chile landscapes using a simulated movement model, cameratrapR: insights on their potential exotic prey dietary subsidy

Diego Ramírez-Alvarez, Xinhai Li

https://doi.org/10.7717/peerj.19946 PubMed 40936771

January 13, 2025

Thermal ecology of the Mexican Garter Snake (Thamnophis eques): temporal and spatial variations

Crystian S. Venegas-Barrera, Armando Sunny, Javier Manjarrez

https://doi.org/10.7717/peerj.18641 PubMed 39822974

September 20, 2024

Ecological and anthropogenic factors influencing the Summer habitat use of Bos gaurus and its conservation threats in Chitwan National Park, Nepal

Surakshya Poudel, Basudev Pokhrel, Bijaya Neupane, Mahamad Sayab Miya, Nishan Kc, Chitra Rekha Basyal, Asmita Neupane, Bijaya Dhami

https://doi.org/10.7717/peerj.18035 PubMed 39314839

June 28, 2024

Microbial fungicides can positively affect aubergine photosynthetic properties, soil enzyme activity and microbial community structure

Longxue Wei, Jinying Zhu, Dongbo Zhao, Yanting Pei, Lianghai Guo, Jianjun Guo, Zhihui Guo, Huini Cui, Yongjun Li, Jiansheng Gao

https://doi.org/10.7717/peerj.17620 PubMed 38952982

April 25, 2024

Natrix natrix after dark: citizen science sheds light on the common grass snake’s nightlife

Petronel Spaseni, Tiberiu C. Sahlean, Iulian Gherghel, Ștefan R. Zamfirescu, Ionuț C. Petreanu, Raluca Melenciuc, Cristina F. Alistar, Viorel D. Gavril, Alexandru Strugariu

https://doi.org/10.7717/peerj.17168 PubMed 38680898

March 29, 2024

Vocal repertoire of Microhyla nilphamariensis from Delhi and comparison with closely related M. ornata populations from the western coast of India and Sri Lanka

Megha Srigyan, Abdus Samad, Abhishek Singh, Jyotsna Karan, Abhishek Chandra, Pooja Gokhale Sinha, Vineeth Kumar, Sandeep Das, Ashish Thomas, Robin Suyesh

https://doi.org/10.7717/peerj.16903 PubMed 38562993

February 29, 2024

The destructive subterranean termite Reticulitermes flavipes (Blattodea: Rhinotermitidae) can colonize arid territories

David Hernández-Teixidor, Aura Pérez-Morín, Juan Pestano, David Mora, Silvia Fajardo

https://doi.org/10.7717/peerj.16936 PubMed 38435985

January 24, 2024

Factors influencing space-use and kill distribution of sympatric lion prides in a semi-arid savanna landscape

Allan Tarugara, Bruce W. Clegg, Sarah B. Clegg

https://doi.org/10.7717/peerj.16749 PubMed 38282863

December 19, 2023

Keep the ball rolling: sexual differences in conglobation behavior of a terrestrial isopod under different degrees of perceived predation pressure

Francisco Javier Zamora-Camacho

https://doi.org/10.7717/peerj.16696 PubMed 38144184

December 1, 2023

Population-level call properties of endangered Dryophytes suweonensissensu lato (Anura: Amphibia) in South Korea

Md Mizanur Rahman, Jiyoung Yun, KaHyun Lee, Seung-Ha Lee, Seung-Min Park, Choong-Ho Ham, Ha-Cheol Sung

https://doi.org/10.7717/peerj.16492 PubMed 38054023

October 17, 2023

Implications of dominance hierarchy on hummingbird-plant interactions in a temperate forest in Northwestern Mexico

Gabriel López-Segoviano, Maribel Arenas-Navarro, Laura E. Nuñez-Rosas, María del Coro Arizmendi

https://doi.org/10.7717/peerj.16245 PubMed 37868051

October 9, 2023

Temporal and spatial patterns of small vertebrate roadkill in a supercity of eastern China

Qiong Wu, Taozhu Sun, Yumeng Zhao, Cong Yu, Junhua Hu, Zhongqiu Li

https://doi.org/10.7717/peerj.16251 PubMed 37842032

September 1, 2023

Improving the success of reinforcement programs: effects of a two-week confinement in a field enclosure on the anti-predator behaviour of captive-bred European hamsters

Julie Fleitz, Manfred R. Enstipp, Emilie Parent, Jonathan Jumeau, Yves Handrich, Mathilde L. Tissier

https://doi.org/10.7717/peerj.15812 PubMed 37671364

June 6, 2023

Assessment of aquatic food web and trophic niche as a measurement of recovery function in restored mangroves in the Southern Gulf of Mexico

Miriam Soria-Barreto, Rosela Pérez-Ceballos, Arturo Zaldívar-Jiménez, Rolando Gelabert Fernández

https://doi.org/10.7717/peerj.15422 PubMed 37304885

September 15, 2022

Bombardier beetles repel invasive bullfrogs

Shinji Sugiura, Tomoki Date

https://doi.org/10.7717/peerj.13805 PubMed 36128194

June 14, 2022

Above- and below-ground trait coordination in tree seedlings depend on the most limiting resource: a test comparing a wet and a dry tropical forest in Mexico

Lucía Sanaphre-Villanueva, Fernando Pineda-García, Wesley Dáttilo, Luisa Fernanda Pinzón-Pérez, Arlett Ricaño-Rocha, Horacio Paz

https://doi.org/10.7717/peerj.13458 PubMed 35722267

June 13, 2022

Factors that influence Cape fur seal predation on Cape gannets at Lambert’s Bay, South Africa

Zanri Strydom, Lauren J. Waller, Mark Brown, Hervé Fritz, Kevin Shaw, Jan A. Venter

https://doi.org/10.7717/peerj.13416 PubMed 35722261

May 17, 2022

Experimentally broadcast ocean surf and river noise alters birdsong

Veronica A. Reed, Cory A. Toth, Ryan N. Wardle, Dylan G.E. Gomes, Jesse R. Barber, Clinton D. Francis

https://doi.org/10.7717/peerj.13297 PubMed 35602893

May 3, 2022

Feature tuning improves MAXENT predictions of the potential distribution of Pedicularis longiflora Rudolph and its variant

Ru Bao, Xiaolong Li, Jianghua Zheng

https://doi.org/10.7717/peerj.13337 PubMed 35529480

April 26, 2022

Dynamics of human take and animal predation on sea turtle nests in Northwest Costa Rica

Janie L. Reavis, Daniela Rojas-Cañizales, Carmen Mejías-Balsalobre, Isabel Naranjo, Randall Arauz, Jesse F. Senko

https://doi.org/10.7717/peerj.12925 PubMed 35497194

March 25, 2022

Polymorphism in a Neotropical toad species: ontogenetic, populational and geographic approaches to chromatic variation in Proceratophrys cristiceps (Müller, 1883) (Amphibia, Anura, Odontophrynidae)

Kleber Silva Vieira, Erivanna Karlene Santos Oliveira, Washington Luiz Silva Vieira, Rômulo Romeu Nóbrega Alves

https://doi.org/10.7717/peerj.12879 PubMed 35356465

March 15, 2022

Spring diet and energy intake of tundra swan (Cygnus columbianus) at the Yellow River National Wetland in Baotou, China

Li Liu, Chao Du, Yan Sun, Wenjing Li, Jiyun Zhang, Litong Cao, Li Gao

https://doi.org/10.7717/peerj.13113 PubMed 35310162

January 3, 2022

Characteristics of Central American brocket deer resting sites in a tropical mountain cloud forest in eastern Mexico

Brenda Muñoz Vazquez, Sonia Gallina Tessaro, Livia León-Paniagua

https://doi.org/10.7717/peerj.12587 PubMed 35036083

November 23, 2021

Five undervalued edible species inherent to autumn-winter season: nutritional composition, bioactive constituents and volatiles profile

Tamara Fukalova Fukalova, María Dolores García Martínez, María Dolores Raigón

https://doi.org/10.7717/peerj.12488 PubMed 34900422

November 9, 2021

Fine-scale plasticity in nest placement can compensate for poor quality junipers as nesting trees for gray vireos

Jonathan Harris, Loren Smith, Scott McMurry

https://doi.org/10.7717/peerj.12477 PubMed 34820199

September 13, 2021

Habitat ephemerality affects the evolution of contrasting growth strategies and cannibalism in anuran larvae

Dogeun Oh, Yongsu Kim, Sohee Yoo, Changku Kang

https://doi.org/10.7717/peerj.12172 PubMed 34603854

September 3, 2021

Beetle bombing always deters praying mantises

Shinji Sugiura

https://doi.org/10.7717/peerj.11657 PubMed 34557341

August 23, 2021

Reef manta rays forage on tidally driven, high density zooplankton patches in Hanifaru Bay, Maldives

Asia O. Armstrong, Guy M.W. Stevens, Kathy A. Townsend, Annie Murray, Michael B. Bennett, Amelia J. Armstrong, Julian Uribe-Palomino, Phil Hosegood, Christine L. Dudgeon, Anthony J. Richardson

https://doi.org/10.7717/peerj.11992 PubMed 34513330

August 12, 2020

Nectar robbing in the trainbearers (Lesbia, Trochilidae)

Boris Igić, Ivory Nguyen, Phillip B. Fenberg

https://doi.org/10.7717/peerj.9561

June 19, 2020

Beyond polyphagy and opportunism: natural prey of hunting spiders in the canopy of apple trees

László Mezőfi, Gábor Markó, Csaba Nagy, Dávid Korányi, Viktor Markó

https://doi.org/10.7717/peerj.9334 PubMed 32596048

April 10, 2020

Evolution of switchable aposematism: insights from individual-based simulations

Woncheol Song, Sang-im Lee, Piotr G. Jablonski

https://doi.org/10.7717/peerj.8915 PubMed 32309047

March 4, 2020

From a calf’s perspective: humpback whale nursing behavior on two US feeding grounds

Jennifer E. Tackaberry, David E. Cade, Jeremy A. Goldbogen, David N. Wiley, Ari S. Friedlaender, Alison K. Stimpert

https://doi.org/10.7717/peerj.8538 PubMed 32181052

February 19, 2020

‘Remote’ behavioural ecology: do megaherbivores consume vegetation in proportion to its presence in the landscape?

Christopher G. Marston, David M. Wilkinson, Matt Sponheimer, Daryl Codron, Jacqui Codron, Hannah J. O’Regan

https://doi.org/10.7717/peerj.8622 PubMed 32117638

February 18, 2020

Personality underground: evidence of behavioral types in the solitary subterranean rodent Ctenomys talarum

María Sol Fanjul, Roxana R. Zenuto

https://doi.org/10.7717/peerj.8490 PubMed 32110481

January 22, 2020

High variability within pet foods prevents the identification of native species in pet cats’ diets using isotopic evaluation

Brandon W. McDonald, Troi Perkins, Robert R. Dunn, Jennifer McDonald, Holly Cole, Robert S. Feranec, Roland Kays

https://doi.org/10.7717/peerj.8337 PubMed 32002325

January 21, 2020

Predicting hedgehog mortality risks on British roads using habitat suitability modelling

Patrick G.R. Wright, Frazer G. Coomber, Chloe C. Bellamy, Sarah E. Perkins, Fiona Mathews

https://doi.org/10.7717/peerj.8154 PubMed 31998548

January 2, 2020

Interspecific differences of stridulatory signals in three species of bark beetles from the genus Polygraphus Er. (Coleoptera: Curculionidae, Scolytinae) inhabiting the island of Sakhalin

Ivan Andreevich Kerchev

https://doi.org/10.7717/peerj.8281 PubMed 31915580

June 13, 2019

Soil respiration and its Q₁₀ response to various grazing systems of a typical steppe in Inner Mongolia, China

Cheng Nie, Yue Li, Lei Niu, Yinghui Liu, Rui Shao, Xia Xu, Yuqiang Tian

https://doi.org/10.7717/peerj.7112 PubMed 31223539

May 13, 2019

Conspecific coprophagy stimulates normal development in a germ-free model invertebrate

Benjamin C. Jahnes, Madeline Herrmann, Zakee L. Sabree

https://doi.org/10.7717/peerj.6914 PubMed 31139506

March 13, 2019

Microgeographic variation in body condition of three Mexican garter snakes in central Mexico

Erika Valencia-Flores, Crystian S. Venegas-Barrera, Victor Fajardo, Javier Manjarrez

https://doi.org/10.7717/peerj.6601 PubMed 30886780

February 20, 2019

Alternative reproductive strategies in black-winged territorial males of Paraphlebia zoe (Odonata, Thaumatoneuridae)

Anais Rivas-Torres, Rosa Ana Sánchez-Guillén, Adolfo Cordero-Rivera

https://doi.org/10.7717/peerj.6489 PubMed 30809457

November 30, 2018

Anti-predator defences of a bombardier beetle: is bombing essential for successful escape from frogs?

Shinji Sugiura

https://doi.org/10.7717/peerj.5942 PubMed 30533294

November 8, 2018

Amphibian life history in a temperate environment of the Mexican Plateau: dimorphism, phenology and trophic ecology of a hylid frog, Hyla eximia (=Dryophytes eximius)

Uriel Hernández-Salinas, Aurelio Ramírez-Bautista, Barry P. Stephenson, Raciel Cruz-Elizalde, Christian Berriozabal-Islas, Carlos Jesús Balderas-Valdivia

https://doi.org/10.7717/peerj.5897 PubMed 30473932

November 6, 2018

Experimental food supplementation increases reproductive effort in the Variable Antshrike in subtropical Brazil

James J. Roper, André M.X. Lima, Angélica M.K. Uejima

https://doi.org/10.7717/peerj.5898 PubMed 30416888

August 15, 2018

Testing ‘Proportion of Females Calving’ as an indicator for population-level reproductive performance for black rhinoceros (Diceros bicornis)

Peter R. Law, Brad Fike

https://doi.org/10.7717/peerj.5430 PubMed 30128200

July 31, 2018

Motion-triggered video cameras reveal spatial and temporal patterns of red fox foraging on carrion provided by mountain lions

Connor O’Malley, L. Mark Elbroch, Patrick E. Lendrum, Howard Quigley

https://doi.org/10.7717/peerj.5324 PubMed 30083459

June 11, 2018

Sex-based differences in anti-predator response of crickets to chemical cues of a mammalian predator

Brian P. Tanis, Bradley Bott, Brian J. Gaston

https://doi.org/10.7717/peerj.4923 PubMed 29910976

February 28, 2018

Precopulatory behavior and sexual conflict in the desert locust

Yiftach Golov, Jan Rillich, Ally Harari, Amir Ayali

https://doi.org/10.7717/peerj.4356 PubMed 29507823

February 20, 2018

Ovary activation does not correlate with pollen and nectar foraging specialization in the bumblebee Bombus impatiens

Meagan A. Simons, Adam R. Smith

https://doi.org/10.7717/peerj.4415 PubMed 29479503

February 9, 2018

A new species of Amazonian snouted treefrog (Hylidae: Scinax) with description of a novel species-habitat association for an aquatic breeding frog

Miquéias Ferrão, Rafael de Fraga, Jiří Moravec, Igor L. Kaefer, Albertina P. Lima

https://doi.org/10.7717/peerj.4321 PubMed 29441233

November 15, 2017

Fitness implications of sex-specific catch-up growth in Nephila senegalensis, a spider with extreme reversed SSD

Rainer Neumann, Nicole Ruppel, Jutta M. Schneider

https://doi.org/10.7717/peerj.4050 PubMed 29158981

November 14, 2017

Intraspecific variation in the diet of the Mexican garter snake Thamnophis eques

Javier Manjarrez, Martha Pacheco-Tinoco, Crystian S. Venegas-Barrera

https://doi.org/10.7717/peerj.4036 PubMed 29158976

November 8, 2017

Visual and acoustic components of courtship in the bird-of-paradise genus Astrapia (Aves: Paradisaeidae)

Edwin Scholes, Julia M. Gillis, Timothy G. Laman

https://doi.org/10.7717/peerj.3987 PubMed 29134145

October 31, 2017

Male-male competition and female choice are differentially affected by male call acoustics in the serrate-legged small treefrog, Kurixalus odontotarsus

Bicheng Zhu, Jichao Wang, Longhui Zhao, Qinghua Chen, Zhixin Sun, Yue Yang, Steven E. Brauth, Yezhong Tang, Jianguo Cui

https://doi.org/10.7717/peerj.3980 PubMed 29104826

August 29, 2017

Relying on known or exploring for new? Movement patterns and reproductive resource use in a tadpole-transporting frog

Kristina B. Beck, Matthias-Claudio Loretto, Max Ringler, Walter Hödl, Andrius Pašukonis

https://doi.org/10.7717/peerj.3745 PubMed 28875083

August 23, 2017

Defensive behaviors of the Oriental armyworm Mythimna separata in response to different parasitoid species (Hymenoptera: Braconidae)

Jincheng Zhou, Ling Meng, Baoping Li

https://doi.org/10.7717/peerj.3690 PubMed 28852593

August 18, 2017

Extended exposure to elevated temperature affects escape response behaviour in coral reef fishes

Donald T. Warren, Jennifer M. Donelson, Mark I. McCormick

https://doi.org/10.7717/peerj.3652 PubMed 28828253

August 17, 2017

Mesoscale spatiotemporal variability in a complex host-parasite system influenced by intermediate host body size

Sara M. Rodríguez, Nelson Valdivia

https://doi.org/10.7717/peerj.3675 PubMed 28828270

July 14, 2017

Development rate rather than social environment influences cognitive performance in Australian black field crickets, Teleogryllus commodus

Caitlin L. Anderson, Michael M. Kasumovic

https://doi.org/10.7717/peerj.3563 PubMed 28717598

May 10, 2017

Cave features, seasonality and subterranean distribution of non-obligate cave dwellers

Enrico Lunghi, Raoul Manenti, Gentile Francesco Ficetola

https://doi.org/10.7717/peerj.3169 PubMed 28503370

April 26, 2017

Density estimates of monarch butterflies overwintering in central Mexico

Wayne E. Thogmartin, Jay E. Diffendorfer, Laura López-Hoffman, Karen Oberhauser, John Pleasants, Brice X. Semmens, Darius Semmens, Orley R. Taylor, Ruscena Wiederholt

https://doi.org/10.7717/peerj.3221 PubMed 28462031

April 18, 2017

Pollinator diversity and reproductive success of Epipactis helleborine (L.) Crantz (Orchidaceae) in anthropogenic and natural habitats

Agnieszka Rewicz, Radomir Jaskuła, Tomasz Rewicz, Grzegorz Tończyk

https://doi.org/10.7717/peerj.3159 PubMed 28439457

February 9, 2017

Acoustic monitoring indicates a correlation between calling and spawning in captive spotted seatrout (Cynoscion nebulosus)

Eric W. Montie, Matt Hoover, Christopher Kehrer, Justin Yost, Karl Brenkert, Tim O’Donnell, Michael R. Denson

https://doi.org/10.7717/peerj.2944 PubMed 28289557

November 1, 2016

Non-target effects of a glyphosate-based herbicide on Common toad larvae (Bufo bufo, Amphibia) and associated algae are altered by temperature

Fabian Baier, Edith Gruber, Thomas Hein, Elisabeth Bondar-Kunze, Marina Ivanković, Axel Mentler, Carsten A. Brühl, Bernhard Spangl, Johann G. Zaller

https://doi.org/10.7717/peerj.2641 PubMed 27833808

October 19, 2016

Residency in white-eared hummingbirds (Hylocharis leucotis) and its effect in territorial contest resolution

Verónica Mendiola-Islas, Carlos Lara, Pablo Corcuera, Pedro Luis Valverde

https://doi.org/10.7717/peerj.2588 PubMed 27781172

June 14, 2016

A unique mating strategy without physical contact during fertilization in Bombay Night Frogs (Nyctibatrachus humayuni) with the description of a new form of amplexus and female call

Bert Willaert, Robin Suyesh, Sonali Garg, Varad B. Giri, Mark A. Bee, S.D. Biju

https://doi.org/10.7717/peerj.2117 PubMed 27326376

April 18, 2016

Old maids have more appeal: effects of age and pheromone source on mate attraction in an orb-web spider

Anna-Lena Cory, Jutta M. Schneider

https://doi.org/10.7717/peerj.1877 PubMed 27114864

March 22, 2016

Lizard movement tracks: variation in path re-use behaviour is consistent with a scent-marking function

Stephan T. Leu, Grant Jackson, John F. Roddick, C. Michael Bull

https://doi.org/10.7717/peerj.1844 PubMed 27019790

March 10, 2016

Updating movement estimates for American black ducks (Anas rubripes)

Orin J. Robinson, Conor P. McGowan, Patrick K. Devers

https://doi.org/10.7717/peerj.1787 PubMed 26989624

December 3, 2015

Sound signatures and production mechanisms of three species of pipefishes (Family: Syngnathidae)

Adam Chee Ooi Lim, Ving Ching Chong, Chiow San Wong, Sithi Vinayakam Muniandy

https://doi.org/10.7717/peerj.1471 PubMed 26734507

November 24, 2015

Are neonicotinoid insecticides driving declines of widespread butterflies?

Andre S. Gilburn, Nils Bunnefeld, John McVean Wilson, Marc S. Botham, Tom M. Brereton, Richard Fox, Dave Goulson

https://doi.org/10.7717/peerj.1402 PubMed 26623186

October 20, 2015

Two continents and two names for a Neotropical colletid bee species (Hymenoptera: Colletidae: Neopasiphaeinae): Hoplocolletes ventralis (Friese, 1924)

Eduardo A.B. Almeida, Fábio B. Quinteiro

https://doi.org/10.7717/peerj.1338 PubMed 26623182

September 24, 2015

Temporal stability of an endemic Mexican treefrog

Griselda Cruz-Ruiz, Crystian S. Venegas-Barrera, Hermilo Sanchez-Sanchez, Javier Manjarrez

https://doi.org/10.7717/peerj.1274 PubMed 26421242

August 25, 2015

Frog eat frog: exploring variables influencing anurophagy

G. John Measey, Giovanni Vimercati, F. André de Villiers, Mohlamatsane M. Mokhatla, Sarah J. Davies, Shelley Edwards, Res Altwegg

https://doi.org/10.7717/peerj.1204 PubMed 26336644

August 13, 2015

Seasonal variation in microhabitat of salamanders: environmental variation or shift of habitat selection?

Enrico Lunghi, Raoul Manenti, Gentile Francesco Ficetola

https://doi.org/10.7717/peerj.1122 PubMed 26290788

August 11, 2015

Prey type and foraging ecology of Sanderlings Calidris alba in different climate zones: are tropical areas more favourable than temperate sites?

Kirsten Grond, Yaa Ntiamoa-Baidu, Theunis Piersma, Jeroen Reneerkens

https://doi.org/10.7717/peerj.1125 PubMed 26290790

August 4, 2015

No evidence that presence of sexually transmitted infection selects for reduced mating rate in the two spot ladybird, Adalia bipunctata

Sophie L. Jones, Daria Pastok, Gregory D.D. Hurst

https://doi.org/10.7717/peerj.1148 PubMed 26290801

June 23, 2015

Life as a bachelor: quantifying the success of an alternative reproductive tactic in male blue monkeys

Su-Jen Roberts, Marina Cords

https://doi.org/10.7717/peerj.1043 PubMed 26131380

May 26, 2015

Using 3D printed eggs to examine the egg-rejection behaviour of wild birds

Branislav Igic, Valerie Nunez, Henning U. Voss, Rebecca Croston, Zachary Aidala, Analía V. López, Aimee Van Tatenhove, Mandë E. Holford, Matthew D. Shawkey, Mark E. Hauber

https://doi.org/10.7717/peerj.965 PubMed 26038720

May 5, 2015

Blood serum and BSA, but neither red blood cells nor hemoglobin can support vitellogenesis and egg production in the dengue vector Aedes aegypti

Kristina K. Gonzales, Hitoshi Tsujimoto, Immo A. Hansen

https://doi.org/10.7717/peerj.938 PubMed 26020000

April 2, 2015

Sloths like it hot: ambient temperature modulates food intake in the brown-throated sloth (Bradypus variegatus)

Rebecca N. Cliffe, Ryan J. Haupt, Judy A. Avey-Arroyo, Rory P. Wilson

https://doi.org/10.7717/peerj.875 PubMed 25861559

April 2, 2015

Conspicuous carotenoid-based pelvic spine ornament in three-spined stickleback populations—occurrence and inheritance

CR Amundsen, JT Nordeide, HM Gjøen, B Larsen, ES Egeland

https://doi.org/10.7717/peerj.872 PubMed 25861558

March 24, 2015

Long live the wasp: adult longevity in captive colonies of the eusocial paper wasp Polistes canadensis (L.)

Robin J. Southon, Emily F. Bell, Peter Graystock, Seirian Sumner

https://doi.org/10.7717/peerj.848 PubMed 25825677