Monitoring algorithm of hospitalized patients in a medical center with SARS-CoV-2 (Omicron variant) infection: clinical epidemiological surveillance and immunological assessment

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Introduction

Materials & Methods

Study design and clinical specimens

RT-PCR testing for SARS-CoV-2 detection

SARS-CoV-2 IgM/IgG detection

SARS-CoV-2 VOC molecular typing

Statistical analyses

Results

Demographic and clinical information of patients with Omicron infection

Anti-N IgM and anti-N IgG serological testing

Relationship between Ct value and infection disease course

Combined antibody and RT-PCR testing in the prognosis of COVID-19

Discussion

Conclusions

Supplemental Information

Additional Information and Declarations

Competing Interests

The authors declare there are no competing interests.

Author Contributions

Chi-Sheng Chen conceived and designed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Ming-Jr Jian conceived and designed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Chih-Kai Chang performed the experiments, prepared figures and/or tables, and approved the final draft.

Hsing-Yi Chung performed the experiments, prepared figures and/or tables, and approved the final draft.

Shih-Yi Li performed the experiments, prepared figures and/or tables, and approved the final draft.

Jung-Chung Lin performed the experiments, prepared figures and/or tables, and approved the final draft.

Kuo-Ming Yeh performed the experiments, prepared figures and/or tables, and approved the final draft.

Ya-Sung Yang performed the experiments, prepared figures and/or tables, and approved the final draft.

Chien-Wen Chen performed the experiments, prepared figures and/or tables, and approved the final draft.

Shan-Shan Hsieh performed the experiments, prepared figures and/or tables, and approved the final draft.

Sheng-Hui Tang performed the experiments, prepared figures and/or tables, and approved the final draft.

Cherng-Lih Perng performed the experiments, prepared figures and/or tables, and approved the final draft.

Feng-Yee Chang conceived and designed the experiments, performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Hung-Sheng Shang conceived and designed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

This study was approved by the Institutional Review Board of Tri-Service General Hospital (TSGHIRB number: C202005041), registered on February 8, 2021. Informed consent was obtained from all the participants involved in the study.

Data Availability

The following information was supplied regarding data availability:

The raw data is available in the Supplemental File.

Funding

This work was supported by the Tri-Service General Hospital, Taipei, Taiwan, R.O.C. [grant number: TSGH-D-111086]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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