Prevalence of HPV genotypes and assessment of their clinical relevance in laryngeal squamous cell carcinoma in a northeastern state of Brazil—a retrospective study

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Microbiology

Main article text

 

Introduction

Materials & Methods

Enrollment and ethics approval

Inclusion criteria

Exclusion criteria

DNA extraction and HPV analysis

Statistical analysis

Results

Discussion

Conclusions

Supplemental Information

Nucleotide sequence of HPVs

DOI: 10.7717/peerj.13684/supp-1

Deidentified patient data

DOI: 10.7717/peerj.13684/supp-2

Additional Information and Declarations

Competing Interests

The authors declare there are no competing interests.

Author Contributions

Charlles Brito performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Rachel D. Cossetti conceived and designed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Diego Agra de Souza analyzed the data, authored or reviewed drafts of the article, and approved the final draft.

Marcos Catanha analyzed the data, authored or reviewed drafts of the article, and approved the final draft.

Pablo de Matos Monteiro performed the experiments, prepared figures and/or tables, and approved the final draft.

Flavia Castello Branco Vidal conceived and designed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

The study was approved by the Ethics in Research Committee of the Federal University of Maranhão (register number 3.023.486).

DNA Deposition

The following information was supplied regarding the deposition of DNA sequences:

The sequences are available at GenBank:

11L: MG850215.1; 14L: MG850244.1; 18L: MN542782.1; 2L: AF548835.1; 23L: MK716218.1; 24L: MG849618.1; 30L: MG849618.1; 31L: MK387724.1; 32L: EF140818.1; 33L: MG849618.1; 35L: MG850334.1; 36L: DQ422750.1; 37L: HE798674.1; 38L: KU707481.1; 39L: MG849618.1; 40L: MK387724.1; 42L: KY595153.1; 43L: HE798668.1; 44L: DQ218252.1; 48L: LC155251.1; 50L: MG849618.1; 51L: MG849618.1; 53L: MG849618.1; 62L: DQ422750.1; 63L: MG850720.1; 64L: MK387724.1; 65L: HE798674.1; 66L: MK387724.1; 69L: KJ571159.1; 71L: JN617898.1; 72L: LC456609.1; 73L: MG848363.1; 75L: MG847721.1; 76L: MG850288.1; 81L: MG848784.1; 82L: LC155238.1; 83L: MK716218.1; 88L: LC155240.1; 104L: MG848784.1.

Data Availability

The following information was supplied regarding data availability:

The raw data is available in the Supplementary File.

Funding

This study was supported by grants from Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão (FAPEMA) UNIVERSAL-00634/18. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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