Association of toll-like receptors single nucleotide polymorphisms with HBV and HCV infection: research status

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Biochemistry, Biophysics and Molecular Biology

Main article text

 

Introduction

Survey methodology

Search strategy

Inclusion criteria

  • Human beings as the object of study.

  • Studies on the relationship between TLRs polymorphisms and the risk of HBV and HCV infection.

  • Studies on the effect of TLRs polymorphisms on the progression and treatment of HBV and HCV-related liver diseases.

  • Only published full-text studies were included.

Exclusion criteria

  • Studies that do not meet the current inclusion criteria.

  • Studies that are irrelevant to the topic.

  • Studies that contain only abstracts but no full text in the database, and they are not available through other means.

  • Reviews, editorials, commentary, abstracts with insufficient data, and conference proceedings (Fig. 2).

SNPs of Toll-like receptors associated with HBV

TLR2 gene

TLR3 gene

TLR4 gene

TLR5 and TLR7 genes

TLR9 gene

SNPs of Toll-like receptors associated with HCV

TLR2 gene

TLR3 gene

TLR4 gene

TLR7 gene

TLR8 and TLR9 genes

Conclusion and Perspectives

Supplemental Information

SNPs of the TLR2 gene associated with HBV

DOI: 10.7717/peerj.13335/supp-1

SNPs of the TLR4 gene associated with HBV

DOI: 10.7717/peerj.13335/supp-2

SNPs of the TLR5 and TLR7 genes associated with HBV

DOI: 10.7717/peerj.13335/supp-3

SNPs of the TLR9 gene associated with HBV

DOI: 10.7717/peerj.13335/supp-4

SNPs of the TLR2 gene associated with HCV

DOI: 10.7717/peerj.13335/supp-5

SNPs of the TLR7 gene associated with HCV

DOI: 10.7717/peerj.13335/supp-6

SNPs of the TLR8 and TLR9 genes associated with HCV

DOI: 10.7717/peerj.13335/supp-7

Additional Information and Declarations

Competing Interests

The authors declare there are no competing interests.

Author Contributions

Yaxin Xu and Wentao Xue conceived and designed the experiments, performed the experiments, prepared figures and/or tables, authored or reviewed drafts of the paper, and approved the final draft.

Hongwei Gao conceived and designed the experiments, performed the experiments, authored or reviewed drafts of the paper, and approved the final draft.

Jiabo Cui and Lingzhi Zhao analyzed the data, prepared figures and/or tables, and approved the final draft.

Chongge You conceived and designed the experiments, authored or reviewed drafts of the paper, and approved the final draft.

Data Availability

The following information was supplied regarding data availability:

This article is a literature review.

Funding

This study was supported by the Lanzhou Science and technology project (grant no.2021-1-104). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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