The leukocyte telomere length, single nucleotide polymorphisms near TERC gene and risk of COPD

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Introduction

Materials and Methods

Patients and controls

Isolation of DNA

Genotyping

Leukocyte telomere length measurement

Statistical analyses

Results

TERCrs12696304 (C > G) SNP

TERC C > T (rs10936599) SNP

Leukocyte telomere length

Discussion

Supplemental Information

Additional Information and Declarations

Competing Interests

The authors declare there are no competing interests.

Author Contributions

Tanya Tacheva performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the paper, and approved the final draft.

Shanbeh Zienolddiny conceived and designed the experiments, analyzed the data, authored or reviewed drafts of the paper, and approved the final draft.

Dimo Dimov conceived and designed the experiments, analyzed the data, prepared figures and/or tables, and approved the final draft.

Denitsa Vlaykova analyzed the data, prepared figures and/or tables, and approved the final draft.

Tatyana Vlaykova conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the paper, and approved the final draft.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

The study protocol was approved by the ethics committee at Medical Faculty, Trakia University, Stara Zagora, Bulgaria and informed consents were obtained from all participants before the study.

Data Availability

The following information was supplied regarding data availability:

The raw data is available in the Supplemental Files.

Funding

The present study was supported by project 3/2019 of the Medical Faculty, Trakia University, (Stara Zagora, Bulgaria). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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