James Melrose

PeerJ Author

Summary

Prof Melroses PhD studies in Edinburgh, Scotland (1978-82) employed fungal taxonomy, mycology, immunology and biochemical techniques to isolate and characterise cereal and fungal araboninoxylanases. He became a postdoctoral Research Fellow in Musculoskeletal disorders at The University of Sydney, Australia (1983-2113) where he investigated tensional and weight bearing musculoskeletal tissues including intervertebral disc, articular cartilage, meniscus, and tendon in health and disease and developed therapeutic stem cell technology for their repair. Dr Melrose is currently Honorary Senior Research Associate at the University of Sydney and Adjunct Professor Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia. He has published 132 scientific papers and 14 book chapters and has consulted on Welcome Foundation (UK), INSERM (France), Netherlands Asthma Foundation, BIRAX Israel-UK Collaborative grants, French National Research Agency (ANR), Estonia National Grant Authority, Hong Kong Regional Grants Council, NHMRC Project and Senior Fellowship Grant Applications. Dr Melrose has been Associate Editor Eur Spine J since 2007.

Anatomy & Physiology Biochemistry Science & Medical Education

Past or current institution affiliations

University of New South Wales

University of Sydney

Work details

Honorary Research Associate

University of Sydney

November 2017

Raymond Purves Bone and Joint Lab, Kolling Institute of Medical Research

Prof Melrose is currently Honorary Senior Research Associate at the Kolling Institute of Medical Research, Royal North Shore Hospital, St. Leonards, NSW 2065, AUSTRALIA.

Adjunct Professor

University of New South Wales

February 2016

Graduate School of Biomedical Engineering

Interests include development of novel bioscaffolds for tissue repair employing mesenchymal stem cells and biotherapeutic viscosupplements.

Websites

June 29, 2018

Achilles and tail tendons of perlecan exon 3 null heparan sulphate deficient mice display surprising improvement in tendon tensile properties and altered collagen fibril organisation compared to C57BL/6 wild type mice

Cindy C. Shu, Margaret M. Smith, Richard C. Appleyard, Christopher B. Little, James Melrose

https://doi.org/10.7717/peerj.5120 PubMed 30042881

March 8, 2018 - Version: 1

Diverse effects of Perlecan-HS on cell and matrix regulation: Tendon destabilization in Hspg2 Exon 3 null HS deficient mice reveals essential homeostatic roles for HS in cellular regulation and tendon functionality

Cindy C Shu, Margaret M Smith, Richard C Appleyard, Christopher B Little, James Melrose

https://doi.org/10.7287/peerj.preprints.26644v1