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Diverse effects of Perlecan-HS on cell and matrix regulation: Tendon destabilization in Hspg2 Exon 3 null HS deficient mice reveals essential homeostatic roles for HS in cellular regulation and tendon functionality

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Diverse effects of Perlecan-HS on cell and matrix regulation: Tendon destabilization in Hspg2 Exon 3 null HS deficient mice reveals essential homeostatic roles for HS in cellular regulation and tendon functionality https://t.co/aHBvzxo0Sw
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Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Cindy C Shu performed the experiments, prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft.

Margaret M Smith conceived and designed the experiments, analyzed the data, approved the final draft, biostatistics, advice on qRTPCR.

Richard C Appleyard conceived and designed the experiments, performed the experiments, contributed reagents/materials/analysis tools, approved the final draft.

Christopher B Little conceived and designed the experiments, analyzed the data, authored or reviewed drafts of the paper, approved the final draft.

James Melrose conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

University of Sydney Animal Care and Ethics Research Committee approved all animal procedures conducted in this study.

Data Deposition

The following information was supplied regarding data availability:

Raw data is stored in the form of an electronic lab book on the Sydney University server. This is a large file specific data for particular figures in the submitted manuscript can be supplied upon request.

Funding

This work was supported by NHMRC Project Grant 1004032. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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