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Jonathan Arch
PeerJ Author
815 Points

Contributions by role

Author 675
Preprint Author 140
Answers 2

Contributions by subject area

Diabetes and Endocrinology
Pharmacology
Metabolic Sciences
Biochemistry
Cell Biology
Nutrition
Translational Medicine
Food Science and Technology

By Q&A topic

Food-science-and-technology
Diabetes-and-endocrinology
Nutrition

Jonathan RS Arch

PeerJ Author

Summary

I spent 27 years in drug discovery in Beecham and SmithKline Beecham, mainly working on obesity and diabetes. My long-term interest has been in the regulation of energy expenditure, especially by beta3-adrenoceptors. I moved to the Clore Laboratory in 2001, where my recent interests have included short chain fatty acid receptors, the influence of maternal nutrition on susceptibility of offspring to metabolic disease, and ligand-directed (biased) signalling via the beta2-adrenoceptor.

Biochemistry Diabetes & Endocrinology

Editorial Board Member

Past or current institution affiliations

University of Buckingham

Work details

Dean of Science and Deputy Director of Metabolic Research

University of Buckingham
Clore Laboratory

Websites

  • Google Scholar

PeerJ Contributions

  • Articles 5
  • Preprints 4
  • Questions 1
August 24, 2020
High fat-fed GPR55 null mice display impaired glucose tolerance without concomitant changes in energy balance or insulin sensitivity but are less responsive to the effects of the cannabinoids rimonabant or Δ(9)-tetrahydrocannabivarin on weight gain
Edward T. Wargent, Malgorzata Kepczynska, Mohamed Sghaier Zaibi, David C. Hislop, Jonathan R.S. Arch, Claire J. Stocker
https://doi.org/10.7717/peerj.9811 PubMed 32904155
January 9, 2018
Preventive effects of Salvia officinalis leaf extract on insulin resistance and inflammation in a model of high fat diet-induced obesity in mice that responds to rosiglitazone
Mohamed R. Ben Khedher, Mohamed Hammami, Jonathan R.S. Arch, David C. Hislop, Dominic Eze, Edward T. Wargent, Małgorzata A. Kępczyńska, Mohamed S. Zaibi
https://doi.org/10.7717/peerj.4166 PubMed 29333341
February 5, 2015
Evidence from studies in rodents and in isolated adipocytes that agonists of the chemerin receptor CMKLR1 may be beneficial in the treatment of type 2 diabetes
Edward T. Wargent, Mohamed S. Zaibi, Jacqueline F. O’Dowd, Michael A. Cawthorne, Steven J. Wang, Jonathan R.S. Arch, Claire J. Stocker
https://doi.org/10.7717/peerj.753 PubMed 25699203
October 7, 2014
Stimulation of glucose uptake in murine soleus muscle and adipocytes by 5-(4-phenoxybutoxy)psoralen (PAP-1) may be mediated by Kv1.5 rather than Kv1.3
Robert A. Ngala, Mohamed S. Zaibi, Kenneth Langlands, Claire J. Stocker, Jonathan R.S. Arch, Michael A. Cawthorne
https://doi.org/10.7717/peerj.614 PubMed 25320682
October 7, 2014
Butyrate and other short-chain fatty acids increase the rate of lipolysis in 3T3-L1 adipocytes
John M. Rumberger, Jonathan R.S. Arch, Allan Green
https://doi.org/10.7717/peerj.611 PubMed 25320679
July 14, 2017 - Version: 1
Preventive effects of salvia officinalis leaf extract on insulin resistance and inflammation, in high fat diet-induced-obesity mice model
Mohamed Raafet Ben Khedher, Mohamed Hammami, Jonathan Robert Arch, David Christopher Hislop, Dominic Anthony Eze, Edward Taynton Wargent, Małgorzata Anna Kępczyńska, Mohamed Sghaier Zaibi
https://doi.org/10.7287/peerj.preprints.3086v1
November 28, 2014 - Version: 1
Evidence from studies in rodents and in isolated adipocytes that agonists of the chemerin receptor CMKLR1 may be beneficial in the treatment of type 2 diabetes
Ed T Wargent, Mohamed S Zaibi, Jacqueline F O'Dowd, Mike A Cawthorne, Steven J Y Wang, Jonathan R S Arch, Claire J Stocker
https://doi.org/10.7287/peerj.preprints.643v1
September 11, 2014 - Version: 1
Stimulation of glucose uptake in murine soleus muscle and adipocytes by 5-(4-phenoxybutoxy)psoralen (PAP-1) may be mediated by Kv1.5 rather than Kv1.3
Robert A Ngala, Mohamed S Zaibi, Kenneth Langlands, Claire J Stocker, Jonathan RS Arch, Michael A Cawthorne
https://doi.org/10.7287/peerj.preprints.498v1
March 28, 2014 - Version: 1
Butyrate and other Short-Chain Fatty Acids Increase the Rate of Lipolysis in 3T3-L1 Adipocytes
John M. Rumberger, Jonathan R.S. Arch, Allan Green
https://doi.org/10.7287/peerj.preprints.312v1

1 Question

0
Decreased energy intake, decreased energy absorption or increased energy expenditure?
about Rice koji reduced body weight gain, fat accumulation, and blood glucose level in high-fat diet-induced obese mice