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Jonathan RS Arch

PeerJ Author

Summary

I spent 27 years in drug discovery in Beecham and SmithKline Beecham, mainly working on obesity and diabetes. My long-term interest has been in the regulation of energy expenditure, especially by beta3-adrenoceptors. I moved to the Clore Laboratory in 2001, where my recent interests have included short chain fatty acid receptors, the influence of maternal nutrition on susceptibility of offspring to metabolic disease, and ligand-directed (biased) signalling via the beta2-adrenoceptor.

Biochemistry Diabetes & Endocrinology

Editing Journals

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University of Buckingham

Work details

Dean of Science and Deputy Director of Metabolic Research

University of Buckingham

Clore Laboratory

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PeerJ Contributions

August 24, 2020

High fat-fed GPR55 null mice display impaired glucose tolerance without concomitant changes in energy balance or insulin sensitivity but are less responsive to the effects of the cannabinoids rimonabant or Δ(9)-tetrahydrocannabivarin on weight gain

Edward T. Wargent, Malgorzata Kepczynska, Mohamed Sghaier Zaibi, David C. Hislop, Jonathan R.S. Arch, Claire J. Stocker

https://doi.org/10.7717/peerj.9811 PubMed 32904155

January 9, 2018

Preventive effects of Salvia officinalis leaf extract on insulin resistance and inflammation in a model of high fat diet-induced obesity in mice that responds to rosiglitazone

Mohamed R. Ben Khedher, Mohamed Hammami, Jonathan R.S. Arch, David C. Hislop, Dominic Eze, Edward T. Wargent, Małgorzata A. Kępczyńska, Mohamed S. Zaibi

https://doi.org/10.7717/peerj.4166 PubMed 29333341

February 5, 2015

Evidence from studies in rodents and in isolated adipocytes that agonists of the chemerin receptor CMKLR1 may be beneficial in the treatment of type 2 diabetes

Edward T. Wargent, Mohamed S. Zaibi, Jacqueline F. O’Dowd, Michael A. Cawthorne, Steven J. Wang, Jonathan R.S. Arch, Claire J. Stocker

https://doi.org/10.7717/peerj.753 PubMed 25699203

October 7, 2014

Stimulation of glucose uptake in murine soleus muscle and adipocytes by 5-(4-phenoxybutoxy)psoralen (PAP-1) may be mediated by Kv1.5 rather than Kv1.3

Robert A. Ngala, Mohamed S. Zaibi, Kenneth Langlands, Claire J. Stocker, Jonathan R.S. Arch, Michael A. Cawthorne

https://doi.org/10.7717/peerj.614 PubMed 25320682

October 7, 2014

Butyrate and other short-chain fatty acids increase the rate of lipolysis in 3T3-L1 adipocytes

John M. Rumberger, Jonathan R.S. Arch, Allan Green

https://doi.org/10.7717/peerj.611 PubMed 25320679

July 14, 2017 - Version: 1

Preventive effects of salvia officinalis leaf extract on insulin resistance and inflammation, in high fat diet-induced-obesity mice model

Mohamed Raafet Ben Khedher, Mohamed Hammami, Jonathan Robert Arch, David Christopher Hislop, Dominic Anthony Eze, Edward Taynton Wargent, Małgorzata Anna Kępczyńska, Mohamed Sghaier Zaibi

https://doi.org/10.7287/peerj.preprints.3086v1

November 28, 2014 - Version: 1

Evidence from studies in rodents and in isolated adipocytes that agonists of the chemerin receptor CMKLR1 may be beneficial in the treatment of type 2 diabetes

Ed T Wargent, Mohamed S Zaibi, Jacqueline F O'Dowd, Mike A Cawthorne, Steven J Y Wang, Jonathan R S Arch, Claire J Stocker

https://doi.org/10.7287/peerj.preprints.643v1

September 11, 2014 - Version: 1

Stimulation of glucose uptake in murine soleus muscle and adipocytes by 5-(4-phenoxybutoxy)psoralen (PAP-1) may be mediated by Kv1.5 rather than Kv1.3

Robert A Ngala, Mohamed S Zaibi, Kenneth Langlands, Claire J Stocker, Jonathan RS Arch, Michael A Cawthorne

https://doi.org/10.7287/peerj.preprints.498v1

March 28, 2014 - Version: 1

Butyrate and other Short-Chain Fatty Acids Increase the Rate of Lipolysis in 3T3-L1 Adipocytes

John M. Rumberger, Jonathan R.S. Arch, Allan Green

https://doi.org/10.7287/peerj.preprints.312v1

1 Question

Decreased energy intake, decreased energy absorption or increased energy expenditure?

about Rice koji reduced body weight gain, fat accumulation, and blood glucose level in high-fat diet-induced obese mice