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Additional Information

Competing Interests

The authors have no competing interests.

Author Contributions

Robert A Ngala conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Mohamed S Zaibi conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Kenneth Langlands conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, reviewed drafts of the paper.

Claire J Stocker conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Jonathan RS Arch conceived and designed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Michael A Cawthorne conceived and designed the experiments, reviewed drafts of the paper, manuscript revision and approval.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

1. University of Buckingham Ethical review Board

2. Animals were killed by an approved method to obtain tissues. Ethical approval numbers for housing and obtaining of tissues: 05/045; 06/016; 06/017; 14/010. Project licence PPL 70/7189.

Funding

This work was funded by The University of Buckingham, supported in part by grant 05/045 from Xention Limited. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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