18 December 2025

The clinical significance of gut microbiota of chronic obstructive pulmonary disease with functional abdominal bloating and distension

"This is a landmark study in respiratory-gastroenterology crossover. It proves the gut microbiome is a missing piece in COPD management and offers actionable, stool-based biomarkers (especially Enterococcus faecium and fungal taxa) for diagnosing and treating FABD."

Rodolfo García-Contreras, Handling Editor

18 December 2025

Preliminary insights into the gut microbiota of patients with rheumatoid arthritis in Vietnam

"Rheumatoid arthritis (RA) affects >20% of joint diseases in Vietnam, increasingly in young patients. This pilot study (22 new RA patients vs. 20 controls) found distinct gut microbiota profiles in RA: enriched Lactococcus, Solobacterium, Faecalibaculum, Corynebacterium; reduced Bacteroides. Profiles correlated with disease activity and antibodies. It highlights gut microbes as potential diagnostic and therapeutic targets in Vietnamese RA."

Rodolfo García-Contreras, Handling Editor

18 December 2025

A systematic review of the role of methylase genes in antibiotic resistance: co-existence with extended spectrum β-lactamase and carbapenemase genes in Klebsiella pneumoniae

"The systematic review discuss the role of key methylase genes (armA, rmtB, rmtC) in K. pneumoniae, which, along with co-existing β-lactamase (blaCTX-M, blaSHV) and carbapenemase (blaKPC, blaNDM) genes, drive resistance to critical antibiotics like aminoglycosides, cephalosporins, and carbapenems. Predominantly reported in Europe and Asia, these resistance mechanisms underscore a global challenge, emphasizing the urgent need for strategic antimicrobial stewardship to combat rising resistance rates."

Rodolfo García-Contreras, Handling Editor

28 November 2025

Genomics, population dynamics, immune evasion and resistance determinants foster the competence and global dissemination of Klebsiella pneumoniae

"This article reveal an important issue of antibiotic resistance among Klebsiella pneumoniae."

Morteza Saki, Handling Editor

26 November 2025

Efflux systems driving resistance and virulence across biological domains

"This research underscores efflux pumps (EPs) as key drivers of multidrug resistance in bacteria, fungi, and cancer cells, while also contributing to virulence, biofilm formation, and persistence. It highlights their role in treatment failure, limitations of current detection methods, and the potential of emerging technologies like CRISPR and efflux pump inhibitors to combat resistance, despite clinical challenges."

Rodolfo García-Contreras, Handling Editor

19 November 2025

Effect of rainfall on metagenomics in a sewage environment in Hongta District, Yuxi city, Yunnan Province

"This study, the first to analyze Hongta District’s sewage microbiome, links high enteric disease prevalence to microbial communities. Metagenomic sequencing showed Proteobacteria dominance, with higher virulence and antibiotic resistance genes in urban areas and dry seasons. These findings highlight the need for improved sewage surveillance and discharge to reduce public health risks."

Rodolfo García-Contreras, Handling Editor

5 November 2025

Biocontrol-relevant diversity of wheat-associated Pseudomonas: prevalence of P. sivasensis and identification of the novel species P. arvensis sp. nov.

"The readership appeal is broad within plant pathology, microbiology, and agricultural sciences, particularly for researchers interested in microbial ecology, biocontrol methods, and crop protection. The integration of genomic data and practical implications for biocontrol enhances its relevance for both academics and applied scientists seeking sustainable solutions to crop diseases."

Sushanta Deb, Handling Editor

24 October 2025

Molecular epidemiology of carbapenem-resistant Escherichia coli in a tertiary hospital located in the Dabie Mountains region, China

"This study, the first to examine carbapenem-resistant Escherichia coli (CREc) in the rural Dabie Mountains, China, analyzed 33 isolates (2018–2022) from elderly patients. Most isolates (97%) produced blaNDM-5 carbapenemases, with resistance to sulfonamides, aminoglycosides, and fosfomycin, and carried virulence genes (e.g., fimH, hlyE). Genomic diversity showed 24 sequence types, with ST410 and ST692 dominant. Findings highlight blaNDM-5-driven resistance and inform regional public health strategies."

Rodolfo García-Contreras, Handling Editor

13 October 2025

Modulation of carbon-to-nitrogen ratio shapes the microbial ecology in a methanol-fed recirculating marine denitrifying reactor

"This study demonstrates that a well-established biofilm can maintain effective denitrification under varying C/N conditions, enhancing the flexibility and efficiency of denitrification systems for treating marine wastewater. This is particularly valuable for sustainable management of closed-circuit systems, reducing reliance on specific carbon sources and improving operational resilience."

Rodolfo García-Contreras, Handling Editor

13 October 2025

Dynamics of the hindgut microbiota of the Japanese honey bees (Apis cerana japonica) throughout the overwintering period

"This study reveals how gut microbiota shift during overwintering in Apis cerana japonica, identifying increases in key bacterial genera and novel candidate species. It highlights the microbiome's potential role in cold stress tolerance, offering insights for probiotic development and improved overwinter survival in honey bees."

Travis Beddoe, Handling Editor