Editor rating: 8 / 10Elena Papaleo –– This work reports a new method for template selection in antibody modeling using the RosettaAntibody framework. It has the potential to improve the accuracy of antibody structure prediction.
Editor rating: 7 / 10Juan J. Morrone –– Interesting contribution on the natural history of a poorly known species.
Editor rating: 8 / 10Jun Chen –– Multiple testing is a fundamental statistical problem in the big data era. Current practices do not consider the auxilary information accompanying the hypotheses, leading to less powerful mutliple testing precedures. This new procedure provides a novel, principled way to use the covariates in the framework of false discovery control, and is expected to be more powerful than the classic procedures when the covariate is informative.
Section Editor rating: 9 / 10Elena Papaleo –– Network theory applied to protein structural ensembles is a powerful paradigm to understand structure-function relationship. This work offers a new solid plugin to explore structures from simulations with graph analysis.
Editor rating: 7 / 10Amanda Toland –– This article identified microRNAs whose expression may be useful for prognosis in colorectal cancer. Findings from this study may help to drive prospective clinical studies to evaluate the utility of these microRNAs.
Editor rating: 7 / 10Jürg Bähler –– This study explores the involvement of both long non-coding and messenger RNAs in host immune and inflammatory responses of piglets to a pathogenic infection with Clostridium.
Editor rating: 7 / 10Keith Crandall –– Really nice venom study on scorpions using transcriptomic data in a phylogenetic context.
Section Editor rating: 8 / 10Elena Papaleo –– To experimentally identify functional short linear motifs (SLiMs) is challenged by their very low affinities. This paper introduces a new computational pipeline to assess how useful a certain protein-protein interaction dataset can be to capture SLiMs. I believe that it will be a very nice tool for many researchers working with protein-protein interactions with in-vitro and cellular assays, as well as for computational biologists.
Editor rating: 7 / 10Jin-Kao Hao –– The work tackles an important topic with an interesting approach and advances the state of the art in the field.
Editor rating: 8 / 10Jürg Bähler –– A new method for reconstructing large transcriptional networks that removes some of the computational bottlenecks of such genome-scale analyses.
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