[Experimental] List of manuscripts available for review volunteers
2 manuscripts available for review volunteers
November 17, 2017
Introduction: Using spatial-temporal analyses to understand coverage and trends in elimination of mother-to-child transmission of HIV (eMTCT) efforts may be helpful in ensuring timely services are delivered to the right place. We present spatial-temporal analysis of 7-years of HIV early infant diagnosis data collected from 12 districts in western Kenya from January 2007 to November 2013, during pre-Option B+ use. Methods: We included in the analysis infants up to one year old. We performed trend analysis using extended Cochran–Mantel–Haenszel stratified test and logistic regression models to examine trends and associations of infant HIV status at first diagnosis with: early diagnosis (<8 weeks after birth), age at specimen collection, infant ever having breastfed, use of single dose nevirapine (sdNVP), and maternal antiretroviral therapy (ART) status. We examined these covariates and fitted spatial and spatial-temporal semi-parametric Poisson regression models to explain HIV-infection rates using R-Integrated Nested Laplace Approximation (INLA) package. We calculated new infections per 100,000 live births and used Quantum GIS to map fitted MTCT estimates for each district in Nyanza region. Results: Median age was 2 months, interquartile range (IQR) 1.5 to 5.8 months. Unadjusted pooled positive rate was 11.8% in the 7-years period and declined from 19.7% in 2007 to 7.0% in 2013, p<0.01. Uptake of testing ≤8 weeks after birth was under 50% in 2007 and increased to 64.1% by 2013, p<0.01. By 2013, the overall case rate was 447 infections per 100,000 live births. Based on Bayesian deviance information criterion comparisons, the spatial-temporal model with maternal and infant covariates was best in explaining geographical variation in MTCT. Discussion: Improved EID uptake and reduced MTCT rates are indicators of progress towards e-MTCT. Co-joined analysis of time and covariates in a spatial context provides a robust approach for explaining differences in programmatic impact over time. Conclusions: During this pre-Option B+ period, the PMTCT program in this region has not achieved e-MTCT target of ≤50 case rates per 100,000 live births. Geographical disparities in program achievements may signify gaps in spatial distribution of e-MTCT efforts and could indicate areas needing further resources and interventions.
November 1, 2017

Background: Kawasaki disease (KD) is an immune-mediated systemic vasculitis and infection plays an important role in the pathophysiology of KD. The susceptibility to infectious disease in patients with KD remains largely unclear. This study aimed to investigate the risk of respiratory tract infection (RTI)-related hospitalizations in children with KD.

Methods: Data from Taiwanese National Health Insurance Research Database was analyzed. Children with KD were selected as KD group and age- and sex-matched non-KD patients were selected as control group with 1:1 ratio. Both cohorts were tracked for 1 year to investigate the incidences of RTI-related hospitalizations. Cox regression hazard model was used to adjust for confounding factors and calculate the adjusted hazard ratio (aHR).

Results: Between January 1996 and December 2012, 13,760 patients with KD were identified as KD group and 13,709 patients were enrolled as control group. An obviously reduced risk of RTI-related hospitalizations was observed in KD patients (aHR: 0.53, 95% confidence interval: 0.49-0.57). The decreased risk persisted through the 1-year follow-up period with a peak protection in 3-6 months (aHR: 0.46, 95% confidence interval: 0.40-0.53).

Conclusions: KD patients had approximately half reduction of risk for RTI-related hospitalizations. The protective effects persisted for at least 1 year. Further studies are warranted to elucidate the entire mechanism and investigate the influences of intravenous immunoglobulin.


Is this open peer review?

No, peer review is still single-blind and all recommendations are private between the authors and Academic Editor. However, any reviewer has the option to sign their report, and once accepted for publication then that review can be shown publicly - again this is optional.

Will I be guaranteed to review if I volunteer?

No. Volunteering is not a guarantee that you will be asked to review. This is for many reasons. For one, reviewers must have relevant qualifications for any manuscript and void of any conflicts of interest. Additionally, it could be that enough reviewers have accepted an invitation to review already, in which case we would not invite any more.

Why aren't there more manuscripts available?

Manuscripts are shown when authors have opted-in for obtaining reviewers through the reviewer-match service. Additionally, there may already be enough reviewers found through other means, for example, invitations sent by the Academic Editor in charge.

What are the editorial criteria?

Please visit the editorial criteria page for initial guidance. You will also be given additional information if invited to review.