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Rajarshi Ghosh
PeerJ Reviewer
105 Points

Contributions by role
Reviewer 105

Contributions by subject area
Biochemistry
Genetics
Oncology
Translational Medicine
Data Mining and Machine Learning
Molecular Biology
Plant Science
Microbiology
Infectious Diseases
Respiratory Medicine
Environmental Impacts
Gastroenterology and Hepatology
Histology
Bioinformatics
Genomics
Animal Behavior
Cognitive Disorders
Geriatrics
Neurology

Rajarshi Ghosh

PeerJ Reviewer

Summary

I have a PhD in Molecular Cellular Biology from UMASS Amherst and 3 years of postdoc experience at Lawrence Berkeley National Lab, followed by 2 years of Postdoc experience at Stanford University Dept of BioEngineering. Currently I am a Life Science research associate at Stanford University, Dept of BioEngineering. I have published extensively in the fields of chromatin structure, protein folding and cancer mechanobiology- in journals such as JBC, MCB, PNAS, Biochemistry, Nature Methods, CSH perspective etc. At the moment I have a first authorship paper under revision in Nature Chemical Biology on the generation of a new class of genetically encoded unbleachable fluorescent tags which is also available through Bioarchive. The projects I am currently working on can be grouped under eight overarching themes: Cancer Mechanobiology, Chromatin Biology, Synthetic Biology, live imaging of mRNA processing and localization, Genetically encoded Fluorescence probes, Genome editing and engineering, Sonogenetics and Optogenetics. These projects interlace broadly the fields of Molecular and Cellular Biology, Physical Chemistry, Genomics, Synthetic Biology, Polymer Physics and Single Molecule Imaging. Previously during my tenure as doctoral student, I used Solution molecular biophysics techniques as well as electron and light microscopy to show that a subset of RETT syndrome result from protein folding defects in Methyl CpG binding protein 2 (MeCP2).

Biochemistry Bioengineering Bioinformatics Biophysics Biotechnology Cell Biology Cognitive Disorders Developmental Biology Genetics Genomics Molecular Biology Neurology Neuroscience Plant Science Synthetic Biology

Past or current institution affiliations

Stanford University

Work details

research associate/ staff scientist

Stanford University
September 2013
bioengineering
I have a PhD in Molecular Cellular Biology from University of Massachusetts Amherst and three years of postdoctoral experience at Lawrence Berkeley National Laboratory in the Physical Bio-sciences division, followed by two years of Postdoctoral experience at Stanford University Department of BioEngineering. Currently I am a Life Science research associate / Staff Scientist at Stanford University, Department of BioEngineering. I have published extensively in the fields of chromatin structure, protein folding and cancer mechanobiology- in journals such as JBC, MCB, PNAS, Biochemistry, Nature Methods, CSH perspective etc. At the moment I have a first authorship paper under revision in Nature Chemical Biology on the generation of a new class of genetically encoded unbleachable fluorescent tags which is also available through Bioarchive. The projects I am currently working on can be grouped under eight overarching themes: Cancer Mechanobiology, Chromatin Biology, Synthetic Biology, live imaging of mRNA processing and localization, Genetically encoded Fluorescence probes, Genome editing and engineering, Sonogenetics and Optogenetics. These projects are strongly interdisciplinary in nature and interlace broadly the fields of Molecular and Cellular Biology, Physical Chemistry, Genomics, Synthetic Biology, Polymer Physics and Single Molecule Imaging. Previously during my tenure as doctoral student, I used Solution molecular biophysics techniques as well as electron and light microscopy to show that a subset of RETT syndrome, a severely debilitating neurological and neuro-developmental disorder, result from protein folding defects in Methyl CpG binding protein 2 (MeCP2), primarily due to a failure in undergoing disorder to order transition upon binding methylated DNA. My doctoral work also showed that MeCP2 exhibits multiple context specific DNA binding modes; exists in a competitive equilibrium with nucleosomal dyad binding proteins such as histone H1 and is one of the fundamental tools used by the cell to translate its epigenetic print into higher order chromatin organization.

post doc

lawrence berkeley national laboratory
September 2010 - August 2013
physical biosciences