Electrical induction hypothesis to explain enhancer-promoter communication
Department of Molecular Medicine, University of Pavia, Pavia, Italy
- Published
- Accepted
- Subject Areas
- Biophysics
- Keywords
- Electrical induction, DNA conductance, DNA replication
- Copyright
- © 2015 Agoni
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ PrePrints) and either DOI or URL of the article must be cited.
- Cite this article
- 2015. Electrical induction hypothesis to explain enhancer-promoter communication. PeerJ PrePrints 3:e950v1 https://doi.org/10.7287/peerj.preprints.950v1
Abstract
The steps of the DNA replication process remains to be clarified. Transcription factors are supposed to find their specific binding-sequence driven by epigenetic modifications and GpC islands. But then how can the replication machinery be able to find the promoters of exactly the genes that the cell needs to transcribe in that moment? Here we hypothesize a role of DNA conductance and electrical induction to give an explanation to this unsolved problem. Our hypothesis goes in accordance with the fact that many authors identified 3D loops in the genomes.
Author Comment
This is an opinion piece.