Multi-scale modelling of E. coli metabolism
Author and article information
Abstract
In response to environmental and genetic perturbations, micro-organisms may regulate their metabolism both metabolically – via metabolite-enzyme interactions – and hierarchically – via modulating enzyme capacities. In this report, we develop a combined metabolic and genetic regulatory model of E. coli that may be used to test this multi-scale response.
Cite this as
2015. Multi-scale modelling of E. coli metabolism. PeerJ PrePrints 3:e914v1 https://doi.org/10.7287/peerj.preprints.914v1Author comment
This report is deliverable 4.6 of the EU FP7 (KBBE) grant 289434 "BioPreDyn: New Bioinformatics Methods and Tools for Data-Driven Predictive Dynamic Modelling in Biotechnological Applications".
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Competing Interests
The authors declare they have no competing interests.
Author Contributions
Kieran Smallbone conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.
Pierre Millard conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.
Data Deposition
The following information was supplied regarding the deposition of related data:
The model described in this report is available through BioModels http://identifiers.org/biomodels.db/MODEL1503050000.
Funding
KS was funded by the EU FP7 (KBBE) grant 289434 "BioPreDyn: New Bioinformatics Methods and Tools for Data-Driven Predictive Dynamic Modelling in Biotechnological Applications". PM was supported by INRA. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.