Non-coding RNAs and the deregulation of ubiquitin-proteasome network in neurodegeneration: a familia tria?
- Published
- Accepted
- Subject Areas
- Molecular Biology, Cognitive Disorders
- Keywords
- miRNAs, ubiquitin, proteasome, miRNAs, neurodegeneration
- Copyright
- © 2015 Persengiev
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ PrePrints) and either DOI or URL of the article must be cited.
- Cite this article
- 2015. Non-coding RNAs and the deregulation of ubiquitin-proteasome network in neurodegeneration: a familia tria? PeerJ PrePrints 3:e796v1 https://doi.org/10.7287/peerj.preprints.796v1
Abstract
Small non-coding RNAs (ncRNAs) represent a diverse group of gene regulatory factors that can posttranscriptionally regulate gene expression in response to various stimuli during brain development and differentiation. Subsets of ncRNAs and miRNAs in particular, are very specifically expressed within the central nervous system and participate in the regulation of important brain functions. miRNAs are essential for the postmitotic survival of neurons, and therefore might play a role in neuroprotection. A number of miRNAs have been reported to be dysregulated in several neurodegenerative diseases implying that they can contribute to pathogenesis. Furthermore, in light of the neuroprotective properties of some miRNAs, these small RNA species may themselves be the focus for drug development. Here, we review recent studies that imply a link between miRNA role in the regulation of ubiquitine-proteasome pathways and neurodegeneration and discuss how increased knowledge of miRNAs might serve the diagnosis and treatment of neurodegenerative diseases.
Author Comment
This review article is a summary of ideas based on previous studies and represents solely the author's views on the subject of miRNAs role in the regulation of protein degradation during neurodegeneration.