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In this article we focus on the role of orexin A in the thermoregulatory functions and its link to food intake. This peptide is named orexin A to emphasize the increase in food intake due to this peptide. The influence of eating behavior could be only secondary to change in the thermoregulatory set-point to reach a determined core temperature. Our viewpoint is compared with vision of other authors, finding possible concordance and disagreement. Activity of the sympathetic nerves system, brown adipose tissue and central body temperatures, heart rate and food intake were monitored to measure the modifications induced by an intracerebroventricular injection of orexin A on the thermoregulation and eating behavior in various experimental conditions.
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