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Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Neil Swainston conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, performed the computation work, reviewed drafts of the paper.

Andrew Currin conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, reviewed drafts of the paper.

Lucy Green performed the experiments, analyzed the data, wrote the paper, reviewed drafts of the paper.

Rainer Breitling analyzed the data, wrote the paper, reviewed drafts of the paper.

Philip J Day analyzed the data, wrote the paper, reviewed drafts of the paper.

Douglas B Kell analyzed the data, wrote the paper, reviewed drafts of the paper.

Data Deposition

The following information was supplied regarding data availability:

https://github.com/synbiochem/CodonGenie

Funding

All authors acknowledge the funding from the Biotechnology and Biological Sciences Research Council (BBSRC; http://www.bbsrc.ac.uk) under grant BB/M017702/1, “Centre for synthetic biology of fine and speciality chemicals (SYNBIOCHEM)”. This is a contribution from the Manchester Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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