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12 Grand Challenges in Single-Cell Data Science

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RT @JrdCamps: Great review discussing 12 challenges of Single-Cell Data Science https://t.co/fd4WiEOGYo via @PeerJPreprints #Singlecell
26 days ago
Great review discussing 12 challenges of Single-Cell Data Science https://t.co/fd4WiEOGYo via @PeerJPreprints #Singlecell
RT @lkmklsmn: Nice review of current Single-Cell Data Science challenges https://t.co/vDwYHyZSpA via @PeerJPreprints
RT @lkmklsmn: Nice review of current Single-Cell Data Science challenges https://t.co/vDwYHyZSpA via @PeerJPreprints
RT @lkmklsmn: Nice review of current Single-Cell Data Science challenges https://t.co/vDwYHyZSpA via @PeerJPreprints
34 days ago
RT @lkmklsmn: Nice review of current Single-Cell Data Science challenges https://t.co/vDwYHyZSpA via @PeerJPreprints
RT @lkmklsmn: Nice review of current Single-Cell Data Science challenges https://t.co/vDwYHyZSpA via @PeerJPreprints
RT @lkmklsmn: Nice review of current Single-Cell Data Science challenges https://t.co/vDwYHyZSpA via @PeerJPreprints
RT @lkmklsmn: Nice review of current Single-Cell Data Science challenges https://t.co/vDwYHyZSpA via @PeerJPreprints
RT @lkmklsmn: Nice review of current Single-Cell Data Science challenges https://t.co/vDwYHyZSpA via @PeerJPreprints
RT @lkmklsmn: Nice review of current Single-Cell Data Science challenges https://t.co/vDwYHyZSpA via @PeerJPreprints
RT @lkmklsmn: Nice review of current Single-Cell Data Science challenges https://t.co/vDwYHyZSpA via @PeerJPreprints
RT @lkmklsmn: Nice review of current Single-Cell Data Science challenges https://t.co/vDwYHyZSpA via @PeerJPreprints
35 days ago
RT @lkmklsmn: Nice review of current Single-Cell Data Science challenges https://t.co/vDwYHyZSpA via @PeerJPreprints
RT @lkmklsmn: Nice review of current Single-Cell Data Science challenges https://t.co/vDwYHyZSpA via @PeerJPreprints
RT @lkmklsmn: Nice review of current Single-Cell Data Science challenges https://t.co/vDwYHyZSpA via @PeerJPreprints
RT @lkmklsmn: Nice review of current Single-Cell Data Science challenges https://t.co/vDwYHyZSpA via @PeerJPreprints
RT @lkmklsmn: Nice review of current Single-Cell Data Science challenges https://t.co/vDwYHyZSpA via @PeerJPreprints
35 days ago
RT @lkmklsmn: Nice review of current Single-Cell Data Science challenges https://t.co/vDwYHyZSpA via @PeerJPreprints
RT @lkmklsmn: Nice review of current Single-Cell Data Science challenges https://t.co/vDwYHyZSpA via @PeerJPreprints
RT @lkmklsmn: Nice review of current Single-Cell Data Science challenges https://t.co/vDwYHyZSpA via @PeerJPreprints
36 days ago
Nice review of current Single-Cell Data Science challenges https://t.co/vDwYHyZSpA via @PeerJPreprints
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Single-Cell Data Science challenges https://t.co/2CF2VINthQ via @PeerJPreprints
RT @hackseq: Single-Cell Data Science challenges https://t.co/6S2IIZlNas via @PeerJPreprints
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Additional Information

Competing Interests

Alice C McHardy is an Academic Editor for PeerJ.

Author Contributions

David Laehnemann prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Johannes Köster prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Ewa Szczurek prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Davis J McCarthy prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Stephanie C Hicks prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Mark D Robinson prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Catalina A Vallejos prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Niko Beerenwinkel prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Kieran R Campbell prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Ahmed Mahfouz authored or reviewed drafts of the paper, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Luca Pinello prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Pavel Skums prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Alexandros Stamatakis authored or reviewed drafts of the paper, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Camille Stephan-Otto Attolini prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Samuel Aparicio approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Jasmijn Baaijens approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Marleen Balvert approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Buys de Barbanson approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Antonio Cappuccio approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Giacomo Corleone approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Bas E Dutilh approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Maria Florescu approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Victor Guryev approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Rens Holmer approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Katharina Jahn approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Thamar Jessurun Lobo prepared figures and/or tables, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Emma M Keizer approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Indu Khatri approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Szymon M Kiełbasa approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Jan O Korbel approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Alexey M Kozlov authored or reviewed drafts of the paper, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Tzu-Hao Kuo authored or reviewed drafts of the paper, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Boudewijn PF Lelieveldt approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Ion I Mandoiu authored or reviewed drafts of the paper, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

John C Marioni approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Tobias Marschall approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Felix Mölder prepared figures and/or tables, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Amir Niknejad approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Łukasz Rączkowski approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Marcel Reinders approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Jeroen de Ridder approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Antoine-Emmanuel Saliba approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Antonios Somarakis approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Oliver Stegle approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Fabian J Theis approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Huan Yang approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Alex Zelikovsky approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Alice C McHardy authored or reviewed drafts of the paper, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Benjamin J Raphael approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Sohrab P Shah approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Alexander Schönhuth prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft, actively participated in the discussions underlying this review, which took place in working groups at the Lorentz workshop "Single Cell Data Science: Making Sense of Data from Billions of Single Cells".

Data Deposition

The following information was supplied regarding data availability:

For this review, no structured data beyond the figures, tables and citations in the main manuscript were used.

Funding

This work was supported by the Canadian Institutes of Health Research (Banting Postdoctoral Fellowship), the Canadian Statistical Sciences Institute (CANSSI, Postdoctoral Fellowship), the UBC Data Science Institute (Postdoctoral Fellowship), the University of Edinburgh (Chancellor's Fellowship), The Alan Turing Institute (EPSRC grant EP/N510129/1), the Helmholtz Society, the Klaus Tschira Foundation, the National Institutes of Health (grant 1R01EB025022), the US National Science Foundation (award 1564936), the UZH URPP Evolution in Action, the Swiss National Science Foundation (310030_175841, CRSII5_177208), the Chan Zuckerberg Initiative DAF / Silicon Valley Community Foundation (2018–182828) and via a Susan G. Komen Scholarship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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