High diversity of vancomycin-resistant Enterococcus faecium isolated in Southern Brazil
- Published
- Accepted
- Subject Areas
- Microbiology, Molecular Biology
- Keywords
- VRE, PFGE, acm gene, esp gene, clonal types
- Copyright
- © 2019 Soares et al.
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ Preprints) and either DOI or URL of the article must be cited.
- Cite this article
- 2019. High diversity of vancomycin-resistant Enterococcus faecium isolated in Southern Brazil. PeerJ Preprints 7:e27817v1 https://doi.org/10.7287/peerj.preprints.27817v1
Abstract
Background. Vancomycin-resistant enterococci (VRE) are common in some hospital settings and their clonal spread has been described in different regions of the world. We determined the antimicrobial susceptibility profile and the clonal relationship of VRE isolates recovered from inpatients at three general hospitals of Porto Alegre, Brazil. Results. Ninety-four VRE were characterized as Enterococcus faecium and exhibited resistance to teicoplanin, ampicillin, ciprofloxacin, and susceptibility to linezolid, quinupristin-dalfopristin and daptomycin. High level resistance to gentamicin was detected in 13.8% of them. All VREfm harbored vanA gene, while 85.1% and 94.7% harbored respectively esp and acm virulence genes. PFGE profile analysis revealed 23 clonal types including 79 isolates, while 15 isolates exhibited unique pattern type, showing a polyclonal distribution of VREfm in Southern Brazil. Conclusion. These findings contribute to the local understanding regarding the characteristics of the circulating VREs in the region.
Author Comment
This is a preprint submission to PeerJ Preprints.