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Additional Information

Competing Interests

Norma Labarthe is a consultant for Bayer animal health, Idexx Laboratories and Zoetis in Brazil. Alexandre Bendas, Marcia Miranda, Jonimar Paiva, Bruno Alberigi and Flavya Mendes-de-Almeida have no conflict of interest.

Author Contributions

Marcia Gonçalves Miranda conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, authored or reviewed drafts of the paper, approved the final draft.

Bruno Alberigi conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, authored or reviewed drafts of the paper, approved the final draft.

Flavya Mendes-de-Almeida conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, authored or reviewed drafts of the paper, approved the final draft.

Alexandre José Rodrigues Bendas conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, authored or reviewed drafts of the paper, approved the final draft.

Nadia Almosny conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, authored or reviewed drafts of the paper, approved the final draft.

Jonimar Pereira Paiva conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, authored or reviewed drafts of the paper, approved the final draft.

Norma Vollmer Labarthe conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, authored or reviewed drafts of the paper, approved the final draft.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

Comitê de Ética em pesquisa animal of the Universidade Federal Fluminense.

Data Deposition

The following information was supplied regarding data availability:

Data are reported in the article.

Funding

Funding was provided by National Council for Scientific and Technological Development (CNPq) and Comissão de Aperfeiçoamento de Pessoal do Nível Superior. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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